Quick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.

<h4>Background</h4>A(δ) and C fibers are the major pain-conducting nerve fibers, activate only partly the same brain areas, and are differently involved in pain syndromes. Whether a stimulus excites predominantly A(δ) or C fibers is a commonly asked question in basic pain research but a...

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Autores principales:	Florian Beissner, Amadeus Brandau, Christian Henke, Lisa Felden, Ulf Baumgärtner, Rolf-Detlef Treede, Bruno G Oertel, Jörn Lötsch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4815551418b34ba998c3aa967ed35f9f
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spelling	oai:doaj.org-article:4815551418b34ba998c3aa967ed35f9f2021-11-18T06:34:52ZQuick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.1932-620310.1371/journal.pone.0012944https://doaj.org/article/4815551418b34ba998c3aa967ed35f9f2010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20886070/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A(δ) and C fibers are the major pain-conducting nerve fibers, activate only partly the same brain areas, and are differently involved in pain syndromes. Whether a stimulus excites predominantly A(δ) or C fibers is a commonly asked question in basic pain research but a quick test was lacking so far.<h4>Methodology/principal findings</h4>Of 77 verbal descriptors of pain sensations, "pricking", "dull" and "pressing" distinguished best (95% cases correctly) between A(δ) fiber mediated (punctate pressure produced by means of von Frey hairs) and C fiber mediated (blunt pressure) pain, applied to healthy volunteers in experiment 1. The sensation was assigned to A(δ) fibers when "pricking" but neither "dull" nor "pressing" were chosen, and to C fibers when the sum of the selections of "dull" or "pressing" was greater than that of the selection of "pricking". In experiment 2, with an independent cohort, the three-descriptor questionnaire achieved sensitivity and specificity above 0.95 for distinguishing fiber preferential non-mechanical induced pain (laser heat, exciting A(δ) fibers, and 5-Hz electric stimulation, exciting C fibers).<h4>Conclusion</h4>A three-item verbal rating test using the words "pricking", "dull", and "pressing" may provide sufficient information to characterize a pain sensation evoked by a physical stimulus as transmitted via A(δ) or via C fibers. It meets the criteria of a screening test by being easy to administer, taking little time, being comfortable in handling, and inexpensive while providing high specificity for relevant information.Florian BeissnerAmadeus BrandauChristian HenkeLisa FeldenUlf BaumgärtnerRolf-Detlef TreedeBruno G OertelJörn LötschPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 9, p e12944 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Florian Beissner Amadeus Brandau Christian Henke Lisa Felden Ulf Baumgärtner Rolf-Detlef Treede Bruno G Oertel Jörn Lötsch Quick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.
description	<h4>Background</h4>A(δ) and C fibers are the major pain-conducting nerve fibers, activate only partly the same brain areas, and are differently involved in pain syndromes. Whether a stimulus excites predominantly A(δ) or C fibers is a commonly asked question in basic pain research but a quick test was lacking so far.<h4>Methodology/principal findings</h4>Of 77 verbal descriptors of pain sensations, "pricking", "dull" and "pressing" distinguished best (95% cases correctly) between A(δ) fiber mediated (punctate pressure produced by means of von Frey hairs) and C fiber mediated (blunt pressure) pain, applied to healthy volunteers in experiment 1. The sensation was assigned to A(δ) fibers when "pricking" but neither "dull" nor "pressing" were chosen, and to C fibers when the sum of the selections of "dull" or "pressing" was greater than that of the selection of "pricking". In experiment 2, with an independent cohort, the three-descriptor questionnaire achieved sensitivity and specificity above 0.95 for distinguishing fiber preferential non-mechanical induced pain (laser heat, exciting A(δ) fibers, and 5-Hz electric stimulation, exciting C fibers).<h4>Conclusion</h4>A three-item verbal rating test using the words "pricking", "dull", and "pressing" may provide sufficient information to characterize a pain sensation evoked by a physical stimulus as transmitted via A(δ) or via C fibers. It meets the criteria of a screening test by being easy to administer, taking little time, being comfortable in handling, and inexpensive while providing high specificity for relevant information.
format	article
author	Florian Beissner Amadeus Brandau Christian Henke Lisa Felden Ulf Baumgärtner Rolf-Detlef Treede Bruno G Oertel Jörn Lötsch
author_facet	Florian Beissner Amadeus Brandau Christian Henke Lisa Felden Ulf Baumgärtner Rolf-Detlef Treede Bruno G Oertel Jörn Lötsch
author_sort	Florian Beissner
title	Quick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.
title_short	Quick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.
title_full	Quick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.
title_fullStr	Quick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.
title_full_unstemmed	Quick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.
title_sort	quick discrimination of a(delta) and c fiber mediated pain based on three verbal descriptors.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/4815551418b34ba998c3aa967ed35f9f
work_keys_str_mv	AT florianbeissner quickdiscriminationofadeltaandcfibermediatedpainbasedonthreeverbaldescriptors AT amadeusbrandau quickdiscriminationofadeltaandcfibermediatedpainbasedonthreeverbaldescriptors AT christianhenke quickdiscriminationofadeltaandcfibermediatedpainbasedonthreeverbaldescriptors AT lisafelden quickdiscriminationofadeltaandcfibermediatedpainbasedonthreeverbaldescriptors AT ulfbaumgartner quickdiscriminationofadeltaandcfibermediatedpainbasedonthreeverbaldescriptors AT rolfdetleftreede quickdiscriminationofadeltaandcfibermediatedpainbasedonthreeverbaldescriptors AT brunogoertel quickdiscriminationofadeltaandcfibermediatedpainbasedonthreeverbaldescriptors AT jornlotsch quickdiscriminationofadeltaandcfibermediatedpainbasedonthreeverbaldescriptors
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Quick discrimination of A(delta) and C fiber mediated pain based on three verbal descriptors.

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