Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation

Suicidal ideation increases precipitously in patients with depression, contributing to the risk of suicidal attempts. Despite the recent advancement in transcranial magnetic stimulation, its effectiveness in depression disorder and its wide acceptance, the network mechanisms of the clinical response...

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Autores principales:	Nailong Tang, Chuanzhu Sun, Yangtao Wang, Xiang Li, Junchang Liu, Yihuan Chen, Liang Sun, Yang Rao, Sanzhong Li, Shun Qi, Huaning Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	individual target-transcranial magnetic stimulation major depressive disorder suicidal ideation functional network connectivity independent component analysis Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/48157c140a1e4106832201568820a421
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spelling	oai:doaj.org-article:48157c140a1e4106832201568820a4212021-11-05T09:50:31ZClinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation1664-064010.3389/fpsyt.2021.768819https://doaj.org/article/48157c140a1e4106832201568820a4212021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.768819/fullhttps://doaj.org/toc/1664-0640Suicidal ideation increases precipitously in patients with depression, contributing to the risk of suicidal attempts. Despite the recent advancement in transcranial magnetic stimulation, its effectiveness in depression disorder and its wide acceptance, the network mechanisms of the clinical response to suicidal ideation in major depressive disorder remain unclear. Independent component analysis for neuroimaging data allows the identification of functional network connectivity which may help to explore the neural basis of suicidal ideation in major depressive disorder. Resting-state functional magnetic resonance imaging data and clinical scales were collected from 30 participants (15 major depressive patients with suicidal ideation and 15 healthy subjects). Individual target-transcranial magnetic stimulation (IT-TMS) was then used to decrease the subgenual anterior cingulate cortex activity through the left dorsolateral prefrontal cortex. Thirty days post IT-TMS therapy, seven of 15 patients (46.67%) met suicidal remission criteria, and 12 patients (80.00%) met depression remission criteria. We found that IT-TMS could restore the abnormal functional network connectivity between default mode network and precuneus network, left executive control network and sensory-motor network. Furthermore, the changes in functional network connectivity between the default mode network and precuneus network were associated with suicidal ideation, and depressive symptoms were related to connectivity between left executive control network and sensory-motor network. These findings illustrate that IT-TMS is an effective protocol for the accurate restoration of impaired brain networks, which is consistent with clinical symptoms.Nailong TangNailong TangChuanzhu SunChuanzhu SunYangtao WangXiang LiXiang LiJunchang LiuYihuan ChenLiang SunYang RaoSanzhong LiShun QiShun QiHuaning WangFrontiers Media S.A.articleindividual target-transcranial magnetic stimulationmajor depressive disordersuicidal ideationfunctional network connectivityindependent component analysisPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	individual target-transcranial magnetic stimulation major depressive disorder suicidal ideation functional network connectivity independent component analysis Psychiatry RC435-571
spellingShingle	individual target-transcranial magnetic stimulation major depressive disorder suicidal ideation functional network connectivity independent component analysis Psychiatry RC435-571 Nailong Tang Nailong Tang Chuanzhu Sun Chuanzhu Sun Yangtao Wang Xiang Li Xiang Li Junchang Liu Yihuan Chen Liang Sun Yang Rao Sanzhong Li Shun Qi Shun Qi Huaning Wang Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation
description	Suicidal ideation increases precipitously in patients with depression, contributing to the risk of suicidal attempts. Despite the recent advancement in transcranial magnetic stimulation, its effectiveness in depression disorder and its wide acceptance, the network mechanisms of the clinical response to suicidal ideation in major depressive disorder remain unclear. Independent component analysis for neuroimaging data allows the identification of functional network connectivity which may help to explore the neural basis of suicidal ideation in major depressive disorder. Resting-state functional magnetic resonance imaging data and clinical scales were collected from 30 participants (15 major depressive patients with suicidal ideation and 15 healthy subjects). Individual target-transcranial magnetic stimulation (IT-TMS) was then used to decrease the subgenual anterior cingulate cortex activity through the left dorsolateral prefrontal cortex. Thirty days post IT-TMS therapy, seven of 15 patients (46.67%) met suicidal remission criteria, and 12 patients (80.00%) met depression remission criteria. We found that IT-TMS could restore the abnormal functional network connectivity between default mode network and precuneus network, left executive control network and sensory-motor network. Furthermore, the changes in functional network connectivity between the default mode network and precuneus network were associated with suicidal ideation, and depressive symptoms were related to connectivity between left executive control network and sensory-motor network. These findings illustrate that IT-TMS is an effective protocol for the accurate restoration of impaired brain networks, which is consistent with clinical symptoms.
format	article
author	Nailong Tang Nailong Tang Chuanzhu Sun Chuanzhu Sun Yangtao Wang Xiang Li Xiang Li Junchang Liu Yihuan Chen Liang Sun Yang Rao Sanzhong Li Shun Qi Shun Qi Huaning Wang
author_facet	Nailong Tang Nailong Tang Chuanzhu Sun Chuanzhu Sun Yangtao Wang Xiang Li Xiang Li Junchang Liu Yihuan Chen Liang Sun Yang Rao Sanzhong Li Shun Qi Shun Qi Huaning Wang
author_sort	Nailong Tang
title	Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation
title_short	Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation
title_full	Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation
title_fullStr	Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation
title_full_unstemmed	Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation
title_sort	clinical response of major depressive disorder patients with suicidal ideation to individual target-transcranial magnetic stimulation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/48157c140a1e4106832201568820a421
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Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation

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