Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon

The drug-coated balloon (DCB) is an emerging percutaneous coronary intervention (PCI) device with theoretical advantages and promising results. Recent clinical observations have demonstrated that DCB tends to have both good efficacy and a good safety profile in the treatment of in-stent restenosis (...

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Autores principales:	Yuxuan Zhang, Xinyi Zhang, Qichao Dong, Delong Chen, Yi Xu, Jun Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	drug-coated balloon dual antiplatelet therapy in-stent restenosis de novo coronary artery disease percutaneous coronary intervention Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/4819b4c1fd2e44ec971ba07863ec9e3e
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spelling	oai:doaj.org-article:4819b4c1fd2e44ec971ba07863ec9e3e2021-12-01T22:33:32ZDuration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon2297-055X10.3389/fcvm.2021.762391https://doaj.org/article/4819b4c1fd2e44ec971ba07863ec9e3e2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.762391/fullhttps://doaj.org/toc/2297-055XThe drug-coated balloon (DCB) is an emerging percutaneous coronary intervention (PCI) device with theoretical advantages and promising results. Recent clinical observations have demonstrated that DCB tends to have both good efficacy and a good safety profile in the treatment of in-stent restenosis (ISR) for both bare-metal and drug-eluting stents (DES), de novo coronary artery disease (CAD), and other situation, such as high bleeding risk, chronic total occlusion, and acute coronary syndrome (ACS). Dual antiplatelet therapy (DAPT) has become an essential medication in daily clinical practice, but the optimal duration of DAPT after the implantation of a DCB remains unknown. At the time of the first in vivo implantation of paclitaxel-DCB for the treatment of ISR in 2006, the protocol-defined DAPT duration was only 1 month. Subsequently, DAPT duration ranging from 1 to 12 months has been recommended by various trials. However, there have been no randomized controlled trials (RCTs) on the optimal duration of DAPT after DCB angioplasty. Current clinical guidelines normally recommend the duration of DAPT after DCB-only angioplasty based on data from RCTs on the optimal duration of DAPT after stenting. In this review, we summarized current clinical trials on DCB-only angioplasty for different types of CADs and their stipulated durations of DAPT, and compared their clinical results such as restenosis, target lesion revascularization (TLR) and stent thrombosis event. We hope this review can assist clinicians in making reasonable decisions about the duration of DAPT after DCB implantation.Yuxuan ZhangXinyi ZhangQichao DongDelong ChenYi XuJun JiangFrontiers Media S.A.articledrug-coated balloondual antiplatelet therapyin-stent restenosisde novo coronary artery diseasepercutaneous coronary interventionDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-coated balloon dual antiplatelet therapy in-stent restenosis de novo coronary artery disease percutaneous coronary intervention Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	drug-coated balloon dual antiplatelet therapy in-stent restenosis de novo coronary artery disease percutaneous coronary intervention Diseases of the circulatory (Cardiovascular) system RC666-701 Yuxuan Zhang Xinyi Zhang Qichao Dong Delong Chen Yi Xu Jun Jiang Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon
description	The drug-coated balloon (DCB) is an emerging percutaneous coronary intervention (PCI) device with theoretical advantages and promising results. Recent clinical observations have demonstrated that DCB tends to have both good efficacy and a good safety profile in the treatment of in-stent restenosis (ISR) for both bare-metal and drug-eluting stents (DES), de novo coronary artery disease (CAD), and other situation, such as high bleeding risk, chronic total occlusion, and acute coronary syndrome (ACS). Dual antiplatelet therapy (DAPT) has become an essential medication in daily clinical practice, but the optimal duration of DAPT after the implantation of a DCB remains unknown. At the time of the first in vivo implantation of paclitaxel-DCB for the treatment of ISR in 2006, the protocol-defined DAPT duration was only 1 month. Subsequently, DAPT duration ranging from 1 to 12 months has been recommended by various trials. However, there have been no randomized controlled trials (RCTs) on the optimal duration of DAPT after DCB angioplasty. Current clinical guidelines normally recommend the duration of DAPT after DCB-only angioplasty based on data from RCTs on the optimal duration of DAPT after stenting. In this review, we summarized current clinical trials on DCB-only angioplasty for different types of CADs and their stipulated durations of DAPT, and compared their clinical results such as restenosis, target lesion revascularization (TLR) and stent thrombosis event. We hope this review can assist clinicians in making reasonable decisions about the duration of DAPT after DCB implantation.
format	article
author	Yuxuan Zhang Xinyi Zhang Qichao Dong Delong Chen Yi Xu Jun Jiang
author_facet	Yuxuan Zhang Xinyi Zhang Qichao Dong Delong Chen Yi Xu Jun Jiang
author_sort	Yuxuan Zhang
title	Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon
title_short	Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon
title_full	Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon
title_fullStr	Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon
title_full_unstemmed	Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon
title_sort	duration of dual antiplatelet therapy after implantation of drug-coated balloon
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4819b4c1fd2e44ec971ba07863ec9e3e
work_keys_str_mv	AT yuxuanzhang durationofdualantiplatelettherapyafterimplantationofdrugcoatedballoon AT xinyizhang durationofdualantiplatelettherapyafterimplantationofdrugcoatedballoon AT qichaodong durationofdualantiplatelettherapyafterimplantationofdrugcoatedballoon AT delongchen durationofdualantiplatelettherapyafterimplantationofdrugcoatedballoon AT yixu durationofdualantiplatelettherapyafterimplantationofdrugcoatedballoon AT junjiang durationofdualantiplatelettherapyafterimplantationofdrugcoatedballoon
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Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon

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