Contributions of Pavlovian incentive motivation to cue-potentiated feeding

Abstract Cues signaling the availability of palatable food acquire the ability to potentiate food seeking and consumption. The current study employed a combination of behavioral, pharmacological, and analytical techniques to probe the role of Pavlovian incentive motivation in cue-potentiated feeding...

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Autores principales:	Andrew T. Marshall, Briac Halbout, Angela T. Liu, Sean B. Ostlund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/482056f316d249c8a85a854265d9b2cc
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spelling	oai:doaj.org-article:482056f316d249c8a85a854265d9b2cc2021-12-02T15:09:01ZContributions of Pavlovian incentive motivation to cue-potentiated feeding10.1038/s41598-018-21046-02045-2322https://doaj.org/article/482056f316d249c8a85a854265d9b2cc2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21046-0https://doaj.org/toc/2045-2322Abstract Cues signaling the availability of palatable food acquire the ability to potentiate food seeking and consumption. The current study employed a combination of behavioral, pharmacological, and analytical techniques to probe the role of Pavlovian incentive motivation in cue-potentiated feeding. We show that a cue paired with sucrose solution (CS+) can transfer its control over feeding to stimulate sucrose consumption at a new receptacle, and that this effect depends on activation of D1 dopamine receptors, which is known to modulate other forms of cue-motivated behavior but not taste palatability. Microstructural analyses of sucrose-licking behavior revealed that the CS+ tended to increase the frequency with which rats engaged in active bouts of licking behavior without having a reliable effect on the duration of those licking bouts, a measure that was instead associated with sucrose palatability. Furthermore, we found that individual differences in CS+ elicited increases in bout frequency were associated with total sucrose intake at test, supporting the view that this process was related to meaningful dysregulation of eating behavior. The current study, therefore, (1) demonstrates that a dopamine-dependent Pavlovian incentive motivational process can mediate cue-potentiated feeding, and (2) lays out an experimental and analytical approach for parsing this aspect of behavior.Andrew T. MarshallBriac HalboutAngela T. LiuSean B. OstlundNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrew T. Marshall Briac Halbout Angela T. Liu Sean B. Ostlund Contributions of Pavlovian incentive motivation to cue-potentiated feeding
description	Abstract Cues signaling the availability of palatable food acquire the ability to potentiate food seeking and consumption. The current study employed a combination of behavioral, pharmacological, and analytical techniques to probe the role of Pavlovian incentive motivation in cue-potentiated feeding. We show that a cue paired with sucrose solution (CS+) can transfer its control over feeding to stimulate sucrose consumption at a new receptacle, and that this effect depends on activation of D1 dopamine receptors, which is known to modulate other forms of cue-motivated behavior but not taste palatability. Microstructural analyses of sucrose-licking behavior revealed that the CS+ tended to increase the frequency with which rats engaged in active bouts of licking behavior without having a reliable effect on the duration of those licking bouts, a measure that was instead associated with sucrose palatability. Furthermore, we found that individual differences in CS+ elicited increases in bout frequency were associated with total sucrose intake at test, supporting the view that this process was related to meaningful dysregulation of eating behavior. The current study, therefore, (1) demonstrates that a dopamine-dependent Pavlovian incentive motivational process can mediate cue-potentiated feeding, and (2) lays out an experimental and analytical approach for parsing this aspect of behavior.
format	article
author	Andrew T. Marshall Briac Halbout Angela T. Liu Sean B. Ostlund
author_facet	Andrew T. Marshall Briac Halbout Angela T. Liu Sean B. Ostlund
author_sort	Andrew T. Marshall
title	Contributions of Pavlovian incentive motivation to cue-potentiated feeding
title_short	Contributions of Pavlovian incentive motivation to cue-potentiated feeding
title_full	Contributions of Pavlovian incentive motivation to cue-potentiated feeding
title_fullStr	Contributions of Pavlovian incentive motivation to cue-potentiated feeding
title_full_unstemmed	Contributions of Pavlovian incentive motivation to cue-potentiated feeding
title_sort	contributions of pavlovian incentive motivation to cue-potentiated feeding
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/482056f316d249c8a85a854265d9b2cc
work_keys_str_mv	AT andrewtmarshall contributionsofpavlovianincentivemotivationtocuepotentiatedfeeding AT briachalbout contributionsofpavlovianincentivemotivationtocuepotentiatedfeeding AT angelatliu contributionsofpavlovianincentivemotivationtocuepotentiatedfeeding AT seanbostlund contributionsofpavlovianincentivemotivationtocuepotentiatedfeeding
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Contributions of Pavlovian incentive motivation to cue-potentiated feeding

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