Vascular surveillance by haptotactic blood platelets in inflammation and infection
Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear. Here, the authors identify haptotaxis as a key effector function of immune-responsive platelets
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Nature Portfolio
2020
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oai:doaj.org-article:4823a6cec2a1460586e33e31ba7a0aef2021-12-02T16:49:15ZVascular surveillance by haptotactic blood platelets in inflammation and infection10.1038/s41467-020-19515-02041-1723https://doaj.org/article/4823a6cec2a1460586e33e31ba7a0aef2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19515-0https://doaj.org/toc/2041-1723Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear. Here, the authors identify haptotaxis as a key effector function of immune-responsive plateletsLeo NicolaiKarin SchiefelbeinSilvia LipskyAlexander LeunigMarie HoffknechtKami PekayvazBen RaudeCharlotte MarxAndreas EhrlichJoachim PircherZhe ZhangInas SalehAnna-Kristina MarelAchim LöfTobias PetzoldMichael LorenzKonstantin StarkRobert PickGerhild RosenbergerLudwig WeckbachBernd UhlSheng XiaChristoph Andreas ReichelBarbara WalzogChristian SchulzVanessa ZhedenMarkus BenderRong LiSteffen MassbergFlorian GaertnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Leo Nicolai Karin Schiefelbein Silvia Lipsky Alexander Leunig Marie Hoffknecht Kami Pekayvaz Ben Raude Charlotte Marx Andreas Ehrlich Joachim Pircher Zhe Zhang Inas Saleh Anna-Kristina Marel Achim Löf Tobias Petzold Michael Lorenz Konstantin Stark Robert Pick Gerhild Rosenberger Ludwig Weckbach Bernd Uhl Sheng Xia Christoph Andreas Reichel Barbara Walzog Christian Schulz Vanessa Zheden Markus Bender Rong Li Steffen Massberg Florian Gaertner Vascular surveillance by haptotactic blood platelets in inflammation and infection |
| description |
Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear. Here, the authors identify haptotaxis as a key effector function of immune-responsive platelets |
| format |
article |
| author |
Leo Nicolai Karin Schiefelbein Silvia Lipsky Alexander Leunig Marie Hoffknecht Kami Pekayvaz Ben Raude Charlotte Marx Andreas Ehrlich Joachim Pircher Zhe Zhang Inas Saleh Anna-Kristina Marel Achim Löf Tobias Petzold Michael Lorenz Konstantin Stark Robert Pick Gerhild Rosenberger Ludwig Weckbach Bernd Uhl Sheng Xia Christoph Andreas Reichel Barbara Walzog Christian Schulz Vanessa Zheden Markus Bender Rong Li Steffen Massberg Florian Gaertner |
| author_facet |
Leo Nicolai Karin Schiefelbein Silvia Lipsky Alexander Leunig Marie Hoffknecht Kami Pekayvaz Ben Raude Charlotte Marx Andreas Ehrlich Joachim Pircher Zhe Zhang Inas Saleh Anna-Kristina Marel Achim Löf Tobias Petzold Michael Lorenz Konstantin Stark Robert Pick Gerhild Rosenberger Ludwig Weckbach Bernd Uhl Sheng Xia Christoph Andreas Reichel Barbara Walzog Christian Schulz Vanessa Zheden Markus Bender Rong Li Steffen Massberg Florian Gaertner |
| author_sort |
Leo Nicolai |
| title |
Vascular surveillance by haptotactic blood platelets in inflammation and infection |
| title_short |
Vascular surveillance by haptotactic blood platelets in inflammation and infection |
| title_full |
Vascular surveillance by haptotactic blood platelets in inflammation and infection |
| title_fullStr |
Vascular surveillance by haptotactic blood platelets in inflammation and infection |
| title_full_unstemmed |
Vascular surveillance by haptotactic blood platelets in inflammation and infection |
| title_sort |
vascular surveillance by haptotactic blood platelets in inflammation and infection |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4823a6cec2a1460586e33e31ba7a0aef |
| work_keys_str_mv |
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1718383393051246592 |