Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp3)-H olefination mediated by donor/donor carbenes

Furanocembranoid-like natural products with the alkene-substituted furan scaffold display a range of biological activities, but are difficult to access. Here, the authors report a modular biomimetic strategy to synthesise diverse alkene-substituted furan-containing macrolactams via palladium-catalys...

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Auteurs principaux: Jiping Hao, Xueying Guo, Shijun He, Zhongliang Xu, Lu Chen, Zhongyu Li, Bichao Song, Jianping Zuo, Zhenyang Lin, Weibo Yang
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/4826f7c7848f4ed781e8fd2e18d65372
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