Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology

Prostate cancer: a “liquid biopsy” test for circulating tumor cells A microfluidic device can rapidly and efficiently isolate circulating tumor cells from the blood of prostate cancer patients. Elodie Sollier-Christen of Vortex Biosciences, Rajan Kulkarni of David Geffen School of Medicine at UCLA,...

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Autores principales:	Corinne Renier, Edward Pao, James Che, Haiyan E. Liu, Clementine A. Lemaire, Melissa Matsumoto, Melanie Triboulet, Sandy Srivinas, Stefanie S. Jeffrey, Matthew Rettig, Rajan P. Kulkarni, Dino Di Carlo, Elodie Sollier-Christen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/48288e4677484c6389f4e410a25bb8ec
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spelling	oai:doaj.org-article:48288e4677484c6389f4e410a25bb8ec2021-12-02T14:22:13ZLabel-free isolation of prostate circulating tumor cells using Vortex microfluidic technology10.1038/s41698-017-0015-02397-768Xhttps://doaj.org/article/48288e4677484c6389f4e410a25bb8ec2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41698-017-0015-0https://doaj.org/toc/2397-768XProstate cancer: a “liquid biopsy” test for circulating tumor cells A microfluidic device can rapidly and efficiently isolate circulating tumor cells from the blood of prostate cancer patients. Elodie Sollier-Christen of Vortex Biosciences, Rajan Kulkarni of David Geffen School of Medicine at UCLA, Dino Di Carlo of UCLA and colleagues tested the company’s microfluidic technology on blood samples taken from 21 men with advanced prostate cancer and 10 healthy controls. They showed that, within an hour, the Vortex Chip could isolate circulating tumor cells in 80% of the cancer patients and that many of these cells did not display the usual surface markers that other approaches require to capture prostate cancer cells. The purities and DNA yields of the isolated cells were high enough to enable targeted genome sequencing, which revealed mutations potentially involved in tumor formation. The Vortex technology could help diagnose prostate cancer and inform therapeutic decision-making for those with the disease.Corinne RenierEdward PaoJames CheHaiyan E. LiuClementine A. LemaireMelissa MatsumotoMelanie TribouletSandy SrivinasStefanie S. JeffreyMatthew RettigRajan P. KulkarniDino Di CarloElodie Sollier-ChristenNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 1, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Corinne Renier Edward Pao James Che Haiyan E. Liu Clementine A. Lemaire Melissa Matsumoto Melanie Triboulet Sandy Srivinas Stefanie S. Jeffrey Matthew Rettig Rajan P. Kulkarni Dino Di Carlo Elodie Sollier-Christen Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology
description	Prostate cancer: a “liquid biopsy” test for circulating tumor cells A microfluidic device can rapidly and efficiently isolate circulating tumor cells from the blood of prostate cancer patients. Elodie Sollier-Christen of Vortex Biosciences, Rajan Kulkarni of David Geffen School of Medicine at UCLA, Dino Di Carlo of UCLA and colleagues tested the company’s microfluidic technology on blood samples taken from 21 men with advanced prostate cancer and 10 healthy controls. They showed that, within an hour, the Vortex Chip could isolate circulating tumor cells in 80% of the cancer patients and that many of these cells did not display the usual surface markers that other approaches require to capture prostate cancer cells. The purities and DNA yields of the isolated cells were high enough to enable targeted genome sequencing, which revealed mutations potentially involved in tumor formation. The Vortex technology could help diagnose prostate cancer and inform therapeutic decision-making for those with the disease.
format	article
author	Corinne Renier Edward Pao James Che Haiyan E. Liu Clementine A. Lemaire Melissa Matsumoto Melanie Triboulet Sandy Srivinas Stefanie S. Jeffrey Matthew Rettig Rajan P. Kulkarni Dino Di Carlo Elodie Sollier-Christen
author_facet	Corinne Renier Edward Pao James Che Haiyan E. Liu Clementine A. Lemaire Melissa Matsumoto Melanie Triboulet Sandy Srivinas Stefanie S. Jeffrey Matthew Rettig Rajan P. Kulkarni Dino Di Carlo Elodie Sollier-Christen
author_sort	Corinne Renier
title	Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology
title_short	Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology
title_full	Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology
title_fullStr	Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology
title_full_unstemmed	Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology
title_sort	label-free isolation of prostate circulating tumor cells using vortex microfluidic technology
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/48288e4677484c6389f4e410a25bb8ec
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Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology

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