A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!

Sickle cell disease (SCD) is a group of hemoglobinopathies that vary in severity, the most severe form, homozygous sickle cell anemia, is more commonly associated with neurologic complications. These are attributed to the vaso-occlusion and micro-obstruction in the circulation of the central nervous...

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Autores principales:	Sangita D Kamath, Manish Ganesh Pai
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	anemia hematoma neurological sickling stroke Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/482924c977244c9298cfcb86df17b474
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spelling	oai:doaj.org-article:482924c977244c9298cfcb86df17b4742021-11-12T10:08:28ZA case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!0973-62471998-356510.4103/ajts.AJTS_101_18https://doaj.org/article/482924c977244c9298cfcb86df17b4742021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=241;epage=246;aulast=Kamathhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565Sickle cell disease (SCD) is a group of hemoglobinopathies that vary in severity, the most severe form, homozygous sickle cell anemia, is more commonly associated with neurologic complications. These are attributed to the vaso-occlusion and micro-obstruction in the circulation of the central nervous system. The incidence of various neurologic complications in SCD ranges from 6% to 30% in various series. The commonly reported in literature include silent cerebral infarction (SCI), ischemic stroke, transient ischemic attacks (TIAs), headaches, seizures and neurocognitive impairment. However, hemorrhagic complications like subarachnoid hemorrhage (SAH), hemorrhagic stroke, extradural and subdural hematomas, especially in absence of trauma are rarely thought of. We report three uncommon spontaneous hemorrhagic manifestations of sickle cell anemia – one case of parenchymal (intracerebral) bleed who presented with acute onset of parkinsonism and two cases of extradural hematoma (EDH) of which one patient had recurrent EDH at the same site which is hitherto not reported in the literature.Sangita D KamathManish Ganesh PaiWolters Kluwer Medknow PublicationsarticleanemiahematomaneurologicalsicklingstrokeDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 241-246 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anemia hematoma neurological sickling stroke Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	anemia hematoma neurological sickling stroke Diseases of the blood and blood-forming organs RC633-647.5 Sangita D Kamath Manish Ganesh Pai A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
description	Sickle cell disease (SCD) is a group of hemoglobinopathies that vary in severity, the most severe form, homozygous sickle cell anemia, is more commonly associated with neurologic complications. These are attributed to the vaso-occlusion and micro-obstruction in the circulation of the central nervous system. The incidence of various neurologic complications in SCD ranges from 6% to 30% in various series. The commonly reported in literature include silent cerebral infarction (SCI), ischemic stroke, transient ischemic attacks (TIAs), headaches, seizures and neurocognitive impairment. However, hemorrhagic complications like subarachnoid hemorrhage (SAH), hemorrhagic stroke, extradural and subdural hematomas, especially in absence of trauma are rarely thought of. We report three uncommon spontaneous hemorrhagic manifestations of sickle cell anemia – one case of parenchymal (intracerebral) bleed who presented with acute onset of parkinsonism and two cases of extradural hematoma (EDH) of which one patient had recurrent EDH at the same site which is hitherto not reported in the literature.
format	article
author	Sangita D Kamath Manish Ganesh Pai
author_facet	Sangita D Kamath Manish Ganesh Pai
author_sort	Sangita D Kamath
title	A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_short	A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_full	A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_fullStr	A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_full_unstemmed	A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_sort	case series of hemorrhagic neurological complications of sickle cell disease: multiple faces of an underestimated problem!
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/482924c977244c9298cfcb86df17b474
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A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!

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