Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients

Nan Zhang,1,2 Marc L Gordon3,4 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 2Department of Neurology and Neurosurgery, Tianjin Medical University General Hospital Airport Hospital, Tianjin, Peop...

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Autores principales:	Zhang N, Gordon ML
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Alzheimer’s disease amnestic mild cognitive impairment donepezil acetylcholinesterase inhibitor efficacy safety Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/482bd02e0f764ba6a6d3d20a5289f17a
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spelling	oai:doaj.org-article:482bd02e0f764ba6a6d3d20a5289f17a2021-12-02T05:44:13ZClinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients1178-1998https://doaj.org/article/482bd02e0f764ba6a6d3d20a5289f17a2018-10-01T00:00:00Zhttps://www.dovepress.com/clinical-efficacy-and-safety-of-donepezil-in-the-treatment-of-alzheime-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Nan Zhang,1,2 Marc L Gordon3,4 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 2Department of Neurology and Neurosurgery, Tianjin Medical University General Hospital Airport Hospital, Tianjin, People’s Republic of China; 3The Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA; 4Departments of Neurology and Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA Abstract: Donepezil, an acetylcholinesterase inhibitor (AChEI), has been widely used to treat Alzheimer’s disease (AD) in China. However, there are few studies focusing on the efficacy and safety of donepezil in Chinese patients. In this review, we discuss 1) the efficacy of donepezil and its comparison with other AChEIs or memantine, 2) the therapeutic responses to donepezil and its influencing factors, and 3) the safety and tolerability of donepezil in Chinese patients with different stages of AD and amnestic mild cognitive impairment, and further compare the similarities and differences of the results between Chinese studies and previous Western studies that predominantly enrolled Caucasian subjects. We include Chinese clinical trials and other well-designed studies investigating donepezil or using donepezil as a positive control, in which the efficacy and/or safety of donepezil have been analyzed. Based on these studies, donepezil has been shown to be effective and safe in Chinese AD patients and may impact AD biomarkers, such as hippocampal atrophy, Aβ, and tau. In addition, the therapeutic response to donepezil may be influenced by apolipoprotein E or cytochrome P450 2D6 polymorphism. Keywords: Alzheimer’s disease, amnestic mild cognitive impairment, donepezil, acetylcholinesterase inhibitor, efficacy, safetyZhang NGordon MLDove Medical PressarticleAlzheimer’s diseaseamnestic mild cognitive impairmentdonepezilacetylcholinesterase inhibitorefficacysafetyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1963-1970 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease amnestic mild cognitive impairment donepezil acetylcholinesterase inhibitor efficacy safety Geriatrics RC952-954.6
spellingShingle	Alzheimer’s disease amnestic mild cognitive impairment donepezil acetylcholinesterase inhibitor efficacy safety Geriatrics RC952-954.6 Zhang N Gordon ML Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients
description	Nan Zhang,1,2 Marc L Gordon3,4 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 2Department of Neurology and Neurosurgery, Tianjin Medical University General Hospital Airport Hospital, Tianjin, People’s Republic of China; 3The Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA; 4Departments of Neurology and Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA Abstract: Donepezil, an acetylcholinesterase inhibitor (AChEI), has been widely used to treat Alzheimer’s disease (AD) in China. However, there are few studies focusing on the efficacy and safety of donepezil in Chinese patients. In this review, we discuss 1) the efficacy of donepezil and its comparison with other AChEIs or memantine, 2) the therapeutic responses to donepezil and its influencing factors, and 3) the safety and tolerability of donepezil in Chinese patients with different stages of AD and amnestic mild cognitive impairment, and further compare the similarities and differences of the results between Chinese studies and previous Western studies that predominantly enrolled Caucasian subjects. We include Chinese clinical trials and other well-designed studies investigating donepezil or using donepezil as a positive control, in which the efficacy and/or safety of donepezil have been analyzed. Based on these studies, donepezil has been shown to be effective and safe in Chinese AD patients and may impact AD biomarkers, such as hippocampal atrophy, Aβ, and tau. In addition, the therapeutic response to donepezil may be influenced by apolipoprotein E or cytochrome P450 2D6 polymorphism. Keywords: Alzheimer’s disease, amnestic mild cognitive impairment, donepezil, acetylcholinesterase inhibitor, efficacy, safety
format	article
author	Zhang N Gordon ML
author_facet	Zhang N Gordon ML
author_sort	Zhang N
title	Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients
title_short	Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients
title_full	Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients
title_fullStr	Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients
title_full_unstemmed	Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients
title_sort	clinical efficacy and safety of donepezil in the treatment of alzheimer’s disease in chinese patients
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/482bd02e0f764ba6a6d3d20a5289f17a
work_keys_str_mv	AT zhangn clinicalefficacyandsafetyofdonepezilinthetreatmentofalzheimerrsquosdiseaseinchinesepatients AT gordonml clinicalefficacyandsafetyofdonepezilinthetreatmentofalzheimerrsquosdiseaseinchinesepatients
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Clinical efficacy and safety of donepezil in the treatment of Alzheimer&rsquo;s disease in Chinese patients

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Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients