Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site

Abstract The monitoring of anthropogenic chemicals in the aquatic environment including their potential effects on aquatic organisms, is important for protecting life under water, a key sustainable development goal. In parallel with monitoring the concentrations of chemicals of concern, sentinel spe...

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Autores principales:	Jaanika Kronberg, Jonathan J. Byrne, Jeroen Jansen, Philipp Antczak, Adam Hines, John Bignell, Ioanna Katsiadaki, Mark R. Viant, Francesco Falciani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/482d7638e4254c6588d577da7644f49b
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spelling	oai:doaj.org-article:482d7638e4254c6588d577da7644f49b2021-12-02T17:23:49ZModeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site10.1038/s41598-021-90494-y2045-2322https://doaj.org/article/482d7638e4254c6588d577da7644f49b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90494-yhttps://doaj.org/toc/2045-2322Abstract The monitoring of anthropogenic chemicals in the aquatic environment including their potential effects on aquatic organisms, is important for protecting life under water, a key sustainable development goal. In parallel with monitoring the concentrations of chemicals of concern, sentinel species are often used to investigate the biological effects of contaminants. Among these, bivalve molluscs such as mussels are filter-feeding and sessile, hence an excellent model system for measuring localized pollution. This study investigates the relationship between the metabolic state of the blue mussel (Mytilus edulis) and its physiology in different environments. We developed a computational model based on a reference site (relatively unpolluted) and integrated seasonal dynamics of metabolite relative concentrations with key physiological indicators and environmental parameters. The analysis of the model revealed that changes in metabolite levels during an annual cycle are influenced by water temperature and are linked to gonadal development. This work supports the importance of data-driven biology and its potential in environmental monitoring.Jaanika KronbergJonathan J. ByrneJeroen JansenPhilipp AntczakAdam HinesJohn BignellIoanna KatsiadakiMark R. ViantFrancesco FalcianiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jaanika Kronberg Jonathan J. Byrne Jeroen Jansen Philipp Antczak Adam Hines John Bignell Ioanna Katsiadaki Mark R. Viant Francesco Falciani Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site
description	Abstract The monitoring of anthropogenic chemicals in the aquatic environment including their potential effects on aquatic organisms, is important for protecting life under water, a key sustainable development goal. In parallel with monitoring the concentrations of chemicals of concern, sentinel species are often used to investigate the biological effects of contaminants. Among these, bivalve molluscs such as mussels are filter-feeding and sessile, hence an excellent model system for measuring localized pollution. This study investigates the relationship between the metabolic state of the blue mussel (Mytilus edulis) and its physiology in different environments. We developed a computational model based on a reference site (relatively unpolluted) and integrated seasonal dynamics of metabolite relative concentrations with key physiological indicators and environmental parameters. The analysis of the model revealed that changes in metabolite levels during an annual cycle are influenced by water temperature and are linked to gonadal development. This work supports the importance of data-driven biology and its potential in environmental monitoring.
format	article
author	Jaanika Kronberg Jonathan J. Byrne Jeroen Jansen Philipp Antczak Adam Hines John Bignell Ioanna Katsiadaki Mark R. Viant Francesco Falciani
author_facet	Jaanika Kronberg Jonathan J. Byrne Jeroen Jansen Philipp Antczak Adam Hines John Bignell Ioanna Katsiadaki Mark R. Viant Francesco Falciani
author_sort	Jaanika Kronberg
title	Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site
title_short	Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site
title_full	Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site
title_fullStr	Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site
title_full_unstemmed	Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site
title_sort	modeling the metabolic profile of mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/482d7638e4254c6588d577da7644f49b
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Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site

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