Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC

Non-small cell lung cancer (NSCLC), a commonly diagnosed lung cancer, is characterized by a high incidence of metastatic spread to the brain, which adversely impacts prognosis. The present study aimed to assess the value of combined dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imag...

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Autores principales: Ye Chengyu, Lin Quanbing, Jin Zhang, Zheng Cuiping, Ma Shenglin
Formato: article
Lenguaje:EN
Publicado: De Gruyter 2021
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Acceso en línea:https://doaj.org/article/4831653aaa8d4e8085839069581ca4fd
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spelling oai:doaj.org-article:4831653aaa8d4e8085839069581ca4fd2021-12-05T14:10:54ZPredictive effect of DCE-MRI and DWI in brain metastases from NSCLC2391-546310.1515/med-2021-0260https://doaj.org/article/4831653aaa8d4e8085839069581ca4fd2021-08-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0260https://doaj.org/toc/2391-5463Non-small cell lung cancer (NSCLC), a commonly diagnosed lung cancer, is characterized by a high incidence of metastatic spread to the brain, which adversely impacts prognosis. The present study aimed to assess the value of combined dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in predicting the treatment outcomes of whole-brain radiotherapy (WBRT) and gefitinib in brain metastases from non-small cell lung cancer (NSCLC) from the perspectives of response rate and short- and long-term efficacy. These results suggested that the indicators measured by DCE-MRI combined with DWI can be used as key imaging-derived markers that predicted the efficacy of WBRT combined with gefitinib in NSCLC patients with brain metastases. Specifically, patients with higher ΔADCmid and ΔADCpost values showed better treatment outcomes. ROC curve analysis indicated ADCpost, ΔADCpost, ΔADCpost (%), and tumor regression rate as the best predictors of efficacy of WBRT combined with gefitinib in these patients. The short-term and long-term effects noted were also significant. Taken together, the findings of this study reveal that tumor regression rate, ADCpost, ΔADCpost, and ΔADCpost (%) can be used as important imaging indicators that predict the therapeutic effect of WBRT combined with gefitinib in NSCLC patients with brain metastases.Ye ChengyuLin QuanbingJin ZhangZheng CuipingMa ShenglinDe Gruyterarticledynamic contrast-enhanced mridiffusion-weighted imagingnon-small cell lung cancerbrain metastasiswhole-brain radiotherapygefitinibMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1265-1275 (2021)
institution DOAJ
collection DOAJ
language EN
topic dynamic contrast-enhanced mri
diffusion-weighted imaging
non-small cell lung cancer
brain metastasis
whole-brain radiotherapy
gefitinib
Medicine
R
spellingShingle dynamic contrast-enhanced mri
diffusion-weighted imaging
non-small cell lung cancer
brain metastasis
whole-brain radiotherapy
gefitinib
Medicine
R
Ye Chengyu
Lin Quanbing
Jin Zhang
Zheng Cuiping
Ma Shenglin
Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC
description Non-small cell lung cancer (NSCLC), a commonly diagnosed lung cancer, is characterized by a high incidence of metastatic spread to the brain, which adversely impacts prognosis. The present study aimed to assess the value of combined dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in predicting the treatment outcomes of whole-brain radiotherapy (WBRT) and gefitinib in brain metastases from non-small cell lung cancer (NSCLC) from the perspectives of response rate and short- and long-term efficacy. These results suggested that the indicators measured by DCE-MRI combined with DWI can be used as key imaging-derived markers that predicted the efficacy of WBRT combined with gefitinib in NSCLC patients with brain metastases. Specifically, patients with higher ΔADCmid and ΔADCpost values showed better treatment outcomes. ROC curve analysis indicated ADCpost, ΔADCpost, ΔADCpost (%), and tumor regression rate as the best predictors of efficacy of WBRT combined with gefitinib in these patients. The short-term and long-term effects noted were also significant. Taken together, the findings of this study reveal that tumor regression rate, ADCpost, ΔADCpost, and ΔADCpost (%) can be used as important imaging indicators that predict the therapeutic effect of WBRT combined with gefitinib in NSCLC patients with brain metastases.
format article
author Ye Chengyu
Lin Quanbing
Jin Zhang
Zheng Cuiping
Ma Shenglin
author_facet Ye Chengyu
Lin Quanbing
Jin Zhang
Zheng Cuiping
Ma Shenglin
author_sort Ye Chengyu
title Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC
title_short Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC
title_full Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC
title_fullStr Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC
title_full_unstemmed Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC
title_sort predictive effect of dce-mri and dwi in brain metastases from nsclc
publisher De Gruyter
publishDate 2021
url https://doaj.org/article/4831653aaa8d4e8085839069581ca4fd
work_keys_str_mv AT yechengyu predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc
AT linquanbing predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc
AT jinzhang predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc
AT zhengcuiping predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc
AT mashenglin predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc
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