Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC
Non-small cell lung cancer (NSCLC), a commonly diagnosed lung cancer, is characterized by a high incidence of metastatic spread to the brain, which adversely impacts prognosis. The present study aimed to assess the value of combined dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imag...
Guardado en:
Autores principales: | , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
De Gruyter
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/4831653aaa8d4e8085839069581ca4fd |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:4831653aaa8d4e8085839069581ca4fd |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:4831653aaa8d4e8085839069581ca4fd2021-12-05T14:10:54ZPredictive effect of DCE-MRI and DWI in brain metastases from NSCLC2391-546310.1515/med-2021-0260https://doaj.org/article/4831653aaa8d4e8085839069581ca4fd2021-08-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0260https://doaj.org/toc/2391-5463Non-small cell lung cancer (NSCLC), a commonly diagnosed lung cancer, is characterized by a high incidence of metastatic spread to the brain, which adversely impacts prognosis. The present study aimed to assess the value of combined dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in predicting the treatment outcomes of whole-brain radiotherapy (WBRT) and gefitinib in brain metastases from non-small cell lung cancer (NSCLC) from the perspectives of response rate and short- and long-term efficacy. These results suggested that the indicators measured by DCE-MRI combined with DWI can be used as key imaging-derived markers that predicted the efficacy of WBRT combined with gefitinib in NSCLC patients with brain metastases. Specifically, patients with higher ΔADCmid and ΔADCpost values showed better treatment outcomes. ROC curve analysis indicated ADCpost, ΔADCpost, ΔADCpost (%), and tumor regression rate as the best predictors of efficacy of WBRT combined with gefitinib in these patients. The short-term and long-term effects noted were also significant. Taken together, the findings of this study reveal that tumor regression rate, ADCpost, ΔADCpost, and ΔADCpost (%) can be used as important imaging indicators that predict the therapeutic effect of WBRT combined with gefitinib in NSCLC patients with brain metastases.Ye ChengyuLin QuanbingJin ZhangZheng CuipingMa ShenglinDe Gruyterarticledynamic contrast-enhanced mridiffusion-weighted imagingnon-small cell lung cancerbrain metastasiswhole-brain radiotherapygefitinibMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1265-1275 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
dynamic contrast-enhanced mri diffusion-weighted imaging non-small cell lung cancer brain metastasis whole-brain radiotherapy gefitinib Medicine R |
spellingShingle |
dynamic contrast-enhanced mri diffusion-weighted imaging non-small cell lung cancer brain metastasis whole-brain radiotherapy gefitinib Medicine R Ye Chengyu Lin Quanbing Jin Zhang Zheng Cuiping Ma Shenglin Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC |
description |
Non-small cell lung cancer (NSCLC), a commonly diagnosed lung cancer, is characterized by a high incidence of metastatic spread to the brain, which adversely impacts prognosis. The present study aimed to assess the value of combined dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in predicting the treatment outcomes of whole-brain radiotherapy (WBRT) and gefitinib in brain metastases from non-small cell lung cancer (NSCLC) from the perspectives of response rate and short- and long-term efficacy. These results suggested that the indicators measured by DCE-MRI combined with DWI can be used as key imaging-derived markers that predicted the efficacy of WBRT combined with gefitinib in NSCLC patients with brain metastases. Specifically, patients with higher ΔADCmid and ΔADCpost values showed better treatment outcomes. ROC curve analysis indicated ADCpost, ΔADCpost, ΔADCpost (%), and tumor regression rate as the best predictors of efficacy of WBRT combined with gefitinib in these patients. The short-term and long-term effects noted were also significant. Taken together, the findings of this study reveal that tumor regression rate, ADCpost, ΔADCpost, and ΔADCpost (%) can be used as important imaging indicators that predict the therapeutic effect of WBRT combined with gefitinib in NSCLC patients with brain metastases. |
format |
article |
author |
Ye Chengyu Lin Quanbing Jin Zhang Zheng Cuiping Ma Shenglin |
author_facet |
Ye Chengyu Lin Quanbing Jin Zhang Zheng Cuiping Ma Shenglin |
author_sort |
Ye Chengyu |
title |
Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC |
title_short |
Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC |
title_full |
Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC |
title_fullStr |
Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC |
title_full_unstemmed |
Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC |
title_sort |
predictive effect of dce-mri and dwi in brain metastases from nsclc |
publisher |
De Gruyter |
publishDate |
2021 |
url |
https://doaj.org/article/4831653aaa8d4e8085839069581ca4fd |
work_keys_str_mv |
AT yechengyu predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc AT linquanbing predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc AT jinzhang predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc AT zhengcuiping predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc AT mashenglin predictiveeffectofdcemrianddwiinbrainmetastasesfromnsclc |
_version_ |
1718371600569466880 |