Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA

Abstract Increasing evidence has demonstrated that lncRNAs are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored. In this study, we evaluated the association between lncRNA and metabolic pathways and identified metaboli...

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Autores principales:	Lingdi Li, Jianfei Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4831bf08ee774dc9a2ac524903919cc8
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spelling	oai:doaj.org-article:4831bf08ee774dc9a2ac524903919cc82021-11-08T10:55:21ZMolecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA10.1038/s41598-021-00410-72045-2322https://doaj.org/article/4831bf08ee774dc9a2ac524903919cc82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00410-7https://doaj.org/toc/2045-2322Abstract Increasing evidence has demonstrated that lncRNAs are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored. In this study, we evaluated the association between lncRNA and metabolic pathways and identified metabolism-related lncRNAs. Gastric cancer can be mainly subdivided into 2 clusters based on these metabolism-related lncRNA regulators. Comparative analysis shows that these subtypes are found to be highly consistent with previously identified subtypes based on other omics data. Functional enrichment analysis shows that they are enriched in distinct biological processes. Mutation analysis shows that ABCA13 is a protective factor in subtype C1 but a risk factor in C2. Analysis of chemotherapeutic and immunotherapeutic sensitivity shows that these subtypes tend to display distinct sensitivity to the same chemical drugs. In conclusion, these findings demonstrated the significance of lncRNA in metabolic regulation. These metabolism-related lncRNA regulators can improve our understanding of the underlying mechanism of lncRNAs and advance the research of immunotherapies in the clinical management of gastric cancer.Lingdi LiJianfei MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingdi Li Jianfei Ma Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA
description	Abstract Increasing evidence has demonstrated that lncRNAs are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored. In this study, we evaluated the association between lncRNA and metabolic pathways and identified metabolism-related lncRNAs. Gastric cancer can be mainly subdivided into 2 clusters based on these metabolism-related lncRNA regulators. Comparative analysis shows that these subtypes are found to be highly consistent with previously identified subtypes based on other omics data. Functional enrichment analysis shows that they are enriched in distinct biological processes. Mutation analysis shows that ABCA13 is a protective factor in subtype C1 but a risk factor in C2. Analysis of chemotherapeutic and immunotherapeutic sensitivity shows that these subtypes tend to display distinct sensitivity to the same chemical drugs. In conclusion, these findings demonstrated the significance of lncRNA in metabolic regulation. These metabolism-related lncRNA regulators can improve our understanding of the underlying mechanism of lncRNAs and advance the research of immunotherapies in the clinical management of gastric cancer.
format	article
author	Lingdi Li Jianfei Ma
author_facet	Lingdi Li Jianfei Ma
author_sort	Lingdi Li
title	Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA
title_short	Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA
title_full	Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA
title_fullStr	Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA
title_full_unstemmed	Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA
title_sort	molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncrna
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4831bf08ee774dc9a2ac524903919cc8
work_keys_str_mv	AT lingdili molecularcharacterizationofmetabolicsubtypesofgastriccancerbasedonmetabolismrelatedlncrna AT jianfeima molecularcharacterizationofmetabolicsubtypesofgastriccancerbasedonmetabolismrelatedlncrna
_version_	1718442519313776640

Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA

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