DNA replication origins retain mobile licensing proteins

Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates that lead up to the loading of an MCM helicase...

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Autores principales:	Humberto Sánchez, Kaley McCluskey, Theo van Laar, Edo van Veen, Filip M. Asscher, Belén Solano, John F. X. Diffley, Nynke H. Dekker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/48341162ccdd441d85b494952e9dc0d4
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spelling	oai:doaj.org-article:48341162ccdd441d85b494952e9dc0d42021-12-02T14:02:51ZDNA replication origins retain mobile licensing proteins10.1038/s41467-021-22216-x2041-1723https://doaj.org/article/48341162ccdd441d85b494952e9dc0d42021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22216-xhttps://doaj.org/toc/2041-1723Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates that lead up to the loading of an MCM helicase onto DNA.Humberto SánchezKaley McCluskeyTheo van LaarEdo van VeenFilip M. AsscherBelén SolanoJohn F. X. DiffleyNynke H. DekkerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Humberto Sánchez Kaley McCluskey Theo van Laar Edo van Veen Filip M. Asscher Belén Solano John F. X. Diffley Nynke H. Dekker DNA replication origins retain mobile licensing proteins
description	Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates that lead up to the loading of an MCM helicase onto DNA.
format	article
author	Humberto Sánchez Kaley McCluskey Theo van Laar Edo van Veen Filip M. Asscher Belén Solano John F. X. Diffley Nynke H. Dekker
author_facet	Humberto Sánchez Kaley McCluskey Theo van Laar Edo van Veen Filip M. Asscher Belén Solano John F. X. Diffley Nynke H. Dekker
author_sort	Humberto Sánchez
title	DNA replication origins retain mobile licensing proteins
title_short	DNA replication origins retain mobile licensing proteins
title_full	DNA replication origins retain mobile licensing proteins
title_fullStr	DNA replication origins retain mobile licensing proteins
title_full_unstemmed	DNA replication origins retain mobile licensing proteins
title_sort	dna replication origins retain mobile licensing proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/48341162ccdd441d85b494952e9dc0d4
work_keys_str_mv	AT humbertosanchez dnareplicationoriginsretainmobilelicensingproteins AT kaleymccluskey dnareplicationoriginsretainmobilelicensingproteins AT theovanlaar dnareplicationoriginsretainmobilelicensingproteins AT edovanveen dnareplicationoriginsretainmobilelicensingproteins AT filipmasscher dnareplicationoriginsretainmobilelicensingproteins AT belensolano dnareplicationoriginsretainmobilelicensingproteins AT johnfxdiffley dnareplicationoriginsretainmobilelicensingproteins AT nynkehdekker dnareplicationoriginsretainmobilelicensingproteins
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DNA replication origins retain mobile licensing proteins

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