Evolutionary advantage of anti-parallel strand orientation of duplex DNA

Abstract DNA in all living systems shares common properties that are remarkably well suited to its function, suggesting refinement by evolution. However, DNA also shares some counter-intuitive properties which confer no obvious benefit, such as strand directionality and anti-parallel strand orientat...

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Autores principales:	Hemachander Subramanian, Robert A. Gatenby
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/48342ba686d942fe8edf01ca39fc07b3
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spelling	oai:doaj.org-article:48342ba686d942fe8edf01ca39fc07b32021-12-02T17:41:05ZEvolutionary advantage of anti-parallel strand orientation of duplex DNA10.1038/s41598-020-66705-32045-2322https://doaj.org/article/48342ba686d942fe8edf01ca39fc07b32020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66705-3https://doaj.org/toc/2045-2322Abstract DNA in all living systems shares common properties that are remarkably well suited to its function, suggesting refinement by evolution. However, DNA also shares some counter-intuitive properties which confer no obvious benefit, such as strand directionality and anti-parallel strand orientation, which together result in the complicated lagging strand replication. The evolutionary dynamics that led to these properties of DNA remain unknown but their universality suggests that they confer as yet unknown selective advantage to DNA. In this article, we identify an evolutionary advantage of anti-parallel strand orientation of duplex DNA, within a given set of plausible premises. The advantage stems from the increased rate of replication, achieved by dividing the DNA into predictable, independently and simultaneously replicating segments, as opposed to sequentially replicating the entire DNA, thereby parallelizing the replication process. We show that anti-parallel strand orientation is essential for such a replicative organization of DNA, given our premises, the most important of which is the assumption of the presence of sequence-dependent asymmetric cooperativity in DNA.Hemachander SubramanianRobert A. GatenbyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hemachander Subramanian Robert A. Gatenby Evolutionary advantage of anti-parallel strand orientation of duplex DNA
description	Abstract DNA in all living systems shares common properties that are remarkably well suited to its function, suggesting refinement by evolution. However, DNA also shares some counter-intuitive properties which confer no obvious benefit, such as strand directionality and anti-parallel strand orientation, which together result in the complicated lagging strand replication. The evolutionary dynamics that led to these properties of DNA remain unknown but their universality suggests that they confer as yet unknown selective advantage to DNA. In this article, we identify an evolutionary advantage of anti-parallel strand orientation of duplex DNA, within a given set of plausible premises. The advantage stems from the increased rate of replication, achieved by dividing the DNA into predictable, independently and simultaneously replicating segments, as opposed to sequentially replicating the entire DNA, thereby parallelizing the replication process. We show that anti-parallel strand orientation is essential for such a replicative organization of DNA, given our premises, the most important of which is the assumption of the presence of sequence-dependent asymmetric cooperativity in DNA.
format	article
author	Hemachander Subramanian Robert A. Gatenby
author_facet	Hemachander Subramanian Robert A. Gatenby
author_sort	Hemachander Subramanian
title	Evolutionary advantage of anti-parallel strand orientation of duplex DNA
title_short	Evolutionary advantage of anti-parallel strand orientation of duplex DNA
title_full	Evolutionary advantage of anti-parallel strand orientation of duplex DNA
title_fullStr	Evolutionary advantage of anti-parallel strand orientation of duplex DNA
title_full_unstemmed	Evolutionary advantage of anti-parallel strand orientation of duplex DNA
title_sort	evolutionary advantage of anti-parallel strand orientation of duplex dna
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/48342ba686d942fe8edf01ca39fc07b3
work_keys_str_mv	AT hemachandersubramanian evolutionaryadvantageofantiparallelstrandorientationofduplexdna AT robertagatenby evolutionaryadvantageofantiparallelstrandorientationofduplexdna
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Evolutionary advantage of anti-parallel strand orientation of duplex DNA

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