Role of darunavir in the management of HIV infection
R Monica Lascar, Paul BennThe Mortimer Market Centre, Camden PCT, London WC1E 6JBAbstract: There is an ongoing need for potent antiretroviral therapies to deal with the increasing pool of treatment-experienced patients with multiple drug resistance. The last few years have seen the arrival of 2 new...
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Dove Medical Press
2009
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oai:doaj.org-article:48349ea0b2f84bd588a17124707ee0d42021-12-02T05:49:20ZRole of darunavir in the management of HIV infection1179-1373https://doaj.org/article/48349ea0b2f84bd588a17124707ee0d42009-11-01T00:00:00Zhttp://www.dovepress.com/role-of-darunavir-in-the-management-of-hiv-infection-a3709https://doaj.org/toc/1179-1373R Monica Lascar, Paul BennThe Mortimer Market Centre, Camden PCT, London WC1E 6JBAbstract: There is an ongoing need for potent antiretroviral therapies to deal with the increasing pool of treatment-experienced patients with multiple drug resistance. The last few years have seen the arrival of 2 new and very potent protease inhibitors – darunavir and tipranavir – alongside 2 whole new classes of anti-HIV agents – the integrase inhibitors and chemokine receptor CCR5 antagonists. This review focuses on the role of darunavir in managing HIV infection, with an emphasis on darunavir’s exceptional resistance profile and related clinical effectiveness, pharmacokinetics, tolerability and toxicity data. Darunavir in combination with the pharmacokinetic booster ritonavir has proved to be very effective in the treatment of highly treatmentexperienced HIV patients with multiple drug resistance. The favorable tolerability and toxicity profile alongside the drug’s high genetic barrier to the development of resistance prompted approval of darunavir for HIV-treatment naïve patients. Furthermore, the paradigm of treating HIV with a combination of anti-HIV agents is currently being challenged by ongoing darunavir monotherapy trials and these preliminary data will be discussed.Keywords: HIV, antiretroviral therapy, darunavir R Monica LascarPaul BennDove Medical PressarticleImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol 2009, Iss Default, Pp 31-39 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 |
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Immunologic diseases. Allergy RC581-607 R Monica Lascar Paul Benn Role of darunavir in the management of HIV infection |
| description |
R Monica Lascar, Paul BennThe Mortimer Market Centre, Camden PCT, London WC1E 6JBAbstract: There is an ongoing need for potent antiretroviral therapies to deal with the increasing pool of treatment-experienced patients with multiple drug resistance. The last few years have seen the arrival of 2 new and very potent protease inhibitors – darunavir and tipranavir – alongside 2 whole new classes of anti-HIV agents – the integrase inhibitors and chemokine receptor CCR5 antagonists. This review focuses on the role of darunavir in managing HIV infection, with an emphasis on darunavir’s exceptional resistance profile and related clinical effectiveness, pharmacokinetics, tolerability and toxicity data. Darunavir in combination with the pharmacokinetic booster ritonavir has proved to be very effective in the treatment of highly treatmentexperienced HIV patients with multiple drug resistance. The favorable tolerability and toxicity profile alongside the drug’s high genetic barrier to the development of resistance prompted approval of darunavir for HIV-treatment naïve patients. Furthermore, the paradigm of treating HIV with a combination of anti-HIV agents is currently being challenged by ongoing darunavir monotherapy trials and these preliminary data will be discussed.Keywords: HIV, antiretroviral therapy, darunavir |
| format |
article |
| author |
R Monica Lascar Paul Benn |
| author_facet |
R Monica Lascar Paul Benn |
| author_sort |
R Monica Lascar |
| title |
Role of darunavir in the management of HIV infection |
| title_short |
Role of darunavir in the management of HIV infection |
| title_full |
Role of darunavir in the management of HIV infection |
| title_fullStr |
Role of darunavir in the management of HIV infection |
| title_full_unstemmed |
Role of darunavir in the management of HIV infection |
| title_sort |
role of darunavir in the management of hiv infection |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/48349ea0b2f84bd588a17124707ee0d4 |
| work_keys_str_mv |
AT rmonicalascar roleofdarunavirinthemanagementofhivinfection AT paulbenn roleofdarunavirinthemanagementofhivinfection |
| _version_ |
1718400225860648960 |