Evaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse

BACKGROUND AND OBJECTIVE: Pelvic organ prolapse (POP) and stress urinary incontinence (SUI) are significantly increased in postmenopausal ages. The mechanism about relation between menopause and SUI is not clear. Perhaps decreased level of hormone induced these problems. Therefore, this study was ca...

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Autores principales:	N Sharife, M Hasanzadeh Mofrad, S Ayate, MT Shakeri, Z Goroneh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	pelvic organ prolapse urinary incontinence estrogen progesterone p53 Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4834e95c96ae447e9425f03a09054ade
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spelling	oai:doaj.org-article:4834e95c96ae447e9425f03a09054ade2021-11-10T08:52:02ZEvaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse1561-41072251-7170https://doaj.org/article/4834e95c96ae447e9425f03a09054ade2012-01-01T00:00:00Zhttp://jbums.org/article-1-3979-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Pelvic organ prolapse (POP) and stress urinary incontinence (SUI) are significantly increased in postmenopausal ages. The mechanism about relation between menopause and SUI is not clear. Perhaps decreased level of hormone induced these problems. Therefore, this study was carried out to assess the relationship between estrogen receptor (ER), progesterone receptor (PR), P53 and the development of SUI and to elucidate the bimolecular pathophysiology of SUI.METHODS: This is a case control study. Ten menopausal women with pelvic organ prolapse and stress urinary incontinence and 10 menopausal women without POP selected for hysterectomy entered into this study. The sample of anterior vaginal walls and uterosacral ligaments were obtained. The relative ER, PR and P53 levels in the samples were obtained by immunohistochemical staining.FINDINGS: The mean age (±SD) of the control group was 56.2±5.6 years and in the sample group it was 56.4±6.8 years. The mean age and the body mass index and the number of vaginal deliveries and the number of years of menopausal in two groups were similar. The P53 in the control group was 14±6.21 and in the sample group was 0.7±0.67. The ER level in the control group was 36±9.36 and in the sample group was 1.20 ±1.61. The PR level in the control group was 42.5±6.34 and in the sample group was 2±1.33. The result in the anterior vaginal wall and uterosacral ligament were similar. Expression of ER and PR and P53 was significant lower in the study group.CONCLUSION: The expression levels of P53, estrogen receptor and progesterone receptor in patients with POP and SUI were significantly lower than the control group.N SharifeM Hasanzadeh MofradS AyateMT ShakeriZ GoronehBabol University of Medical Sciencesarticlepelvic organ prolapseurinary incontinenceestrogenprogesteronep53MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 1, Pp 25-30 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	pelvic organ prolapse urinary incontinence estrogen progesterone p53 Medicine R Medicine (General) R5-920
spellingShingle	pelvic organ prolapse urinary incontinence estrogen progesterone p53 Medicine R Medicine (General) R5-920 N Sharife M Hasanzadeh Mofrad S Ayate MT Shakeri Z Goroneh Evaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse
description	BACKGROUND AND OBJECTIVE: Pelvic organ prolapse (POP) and stress urinary incontinence (SUI) are significantly increased in postmenopausal ages. The mechanism about relation between menopause and SUI is not clear. Perhaps decreased level of hormone induced these problems. Therefore, this study was carried out to assess the relationship between estrogen receptor (ER), progesterone receptor (PR), P53 and the development of SUI and to elucidate the bimolecular pathophysiology of SUI.METHODS: This is a case control study. Ten menopausal women with pelvic organ prolapse and stress urinary incontinence and 10 menopausal women without POP selected for hysterectomy entered into this study. The sample of anterior vaginal walls and uterosacral ligaments were obtained. The relative ER, PR and P53 levels in the samples were obtained by immunohistochemical staining.FINDINGS: The mean age (±SD) of the control group was 56.2±5.6 years and in the sample group it was 56.4±6.8 years. The mean age and the body mass index and the number of vaginal deliveries and the number of years of menopausal in two groups were similar. The P53 in the control group was 14±6.21 and in the sample group was 0.7±0.67. The ER level in the control group was 36±9.36 and in the sample group was 1.20 ±1.61. The PR level in the control group was 42.5±6.34 and in the sample group was 2±1.33. The result in the anterior vaginal wall and uterosacral ligament were similar. Expression of ER and PR and P53 was significant lower in the study group.CONCLUSION: The expression levels of P53, estrogen receptor and progesterone receptor in patients with POP and SUI were significantly lower than the control group.
format	article
author	N Sharife M Hasanzadeh Mofrad S Ayate MT Shakeri Z Goroneh
author_facet	N Sharife M Hasanzadeh Mofrad S Ayate MT Shakeri Z Goroneh
author_sort	N Sharife
title	Evaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse
title_short	Evaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse
title_full	Evaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse
title_fullStr	Evaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse
title_full_unstemmed	Evaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse
title_sort	evaluation of expression estrogen receptor and progesterone receptor and p53 in patients with stress urinary incontinence and pelvic organ prolapse
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/4834e95c96ae447e9425f03a09054ade
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Evaluation of Expression Estrogen Receptor and Progesterone Receptor and P53 in Patients with Stress Urinary Incontinence and Pelvic Organ Prolapse

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