Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.

Impaired exercise tolerance and lung function is a marker for increased mortality in lung cancer patients undergoing lung resection surgery. Recent data suggest that the gut-lung axis regulates systemic metabolic and immune functions, and microbiota might alter exercise tolerance. Here, we aimed to...

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Autores principales:	Andrea Marfil-Sánchez, Bastian Seelbinder, Yueqiong Ni, Janos Varga, Judit Berta, Virag Hollosi, Balazs Dome, Zsolt Megyesfalvi, Edit Dulka, Gabriella Galffy, Glen J Weiss, Gianni Panagiotou, Zoltan Lohinai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/483878630d314d5e98e0ea3f69b3fa9a
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spelling	oai:doaj.org-article:483878630d314d5e98e0ea3f69b3fa9a2021-12-02T20:12:49ZGut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.1932-620310.1371/journal.pone.0259898https://doaj.org/article/483878630d314d5e98e0ea3f69b3fa9a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259898https://doaj.org/toc/1932-6203Impaired exercise tolerance and lung function is a marker for increased mortality in lung cancer patients undergoing lung resection surgery. Recent data suggest that the gut-lung axis regulates systemic metabolic and immune functions, and microbiota might alter exercise tolerance. Here, we aimed to evaluate the associations between gut microbiota and outcomes in lung cancer patients who underwent lung resection surgery. We analysed stool samples, from 15 early-stage lung cancer patients, collected before and after surgical resection using shotgun metagenomic and Internal Transcribed Spacer (ITS) sequencing. We analysed microbiome and mycobiome associations with post-surgery lung function and cardiopulmonary exercise testing (CPET) to assess the maximum level of work achieved. There was a significant difference, between pre- and post-surgical resection samples, in microbial community functional profiles and several species from Alistipes and Bacteroides genus, associated with the production of SCFAs, increased significantly in abundance. Interestingly, an increase in VO2 coincides with an increase in certain species and the "GABA shunt" pathway, suggesting that treatment outcome might improve by enriching butyrate-producing species. Here, we revealed associations between specific gut bacteria, fungi, and their metabolic pathways with the recovery of lung function and exercise capacity.Andrea Marfil-SánchezBastian SeelbinderYueqiong NiJanos VargaJudit BertaVirag HollosiBalazs DomeZsolt MegyesfalviEdit DulkaGabriella GalffyGlen J WeissGianni PanagiotouZoltan LohinaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259898 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Marfil-Sánchez Bastian Seelbinder Yueqiong Ni Janos Varga Judit Berta Virag Hollosi Balazs Dome Zsolt Megyesfalvi Edit Dulka Gabriella Galffy Glen J Weiss Gianni Panagiotou Zoltan Lohinai Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.
description	Impaired exercise tolerance and lung function is a marker for increased mortality in lung cancer patients undergoing lung resection surgery. Recent data suggest that the gut-lung axis regulates systemic metabolic and immune functions, and microbiota might alter exercise tolerance. Here, we aimed to evaluate the associations between gut microbiota and outcomes in lung cancer patients who underwent lung resection surgery. We analysed stool samples, from 15 early-stage lung cancer patients, collected before and after surgical resection using shotgun metagenomic and Internal Transcribed Spacer (ITS) sequencing. We analysed microbiome and mycobiome associations with post-surgery lung function and cardiopulmonary exercise testing (CPET) to assess the maximum level of work achieved. There was a significant difference, between pre- and post-surgical resection samples, in microbial community functional profiles and several species from Alistipes and Bacteroides genus, associated with the production of SCFAs, increased significantly in abundance. Interestingly, an increase in VO2 coincides with an increase in certain species and the "GABA shunt" pathway, suggesting that treatment outcome might improve by enriching butyrate-producing species. Here, we revealed associations between specific gut bacteria, fungi, and their metabolic pathways with the recovery of lung function and exercise capacity.
format	article
author	Andrea Marfil-Sánchez Bastian Seelbinder Yueqiong Ni Janos Varga Judit Berta Virag Hollosi Balazs Dome Zsolt Megyesfalvi Edit Dulka Gabriella Galffy Glen J Weiss Gianni Panagiotou Zoltan Lohinai
author_facet	Andrea Marfil-Sánchez Bastian Seelbinder Yueqiong Ni Janos Varga Judit Berta Virag Hollosi Balazs Dome Zsolt Megyesfalvi Edit Dulka Gabriella Galffy Glen J Weiss Gianni Panagiotou Zoltan Lohinai
author_sort	Andrea Marfil-Sánchez
title	Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.
title_short	Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.
title_full	Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.
title_fullStr	Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.
title_full_unstemmed	Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.
title_sort	gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/483878630d314d5e98e0ea3f69b3fa9a
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Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.

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