Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome
Abstract Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asympto...
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Nature Portfolio
2021
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oai:doaj.org-article:48388a72aa544be0b4f9b09adc2f6ea22021-11-28T12:15:47ZUpregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome10.1038/s41598-021-02489-42045-2322https://doaj.org/article/48388a72aa544be0b4f9b09adc2f6ea22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02489-4https://doaj.org/toc/2045-2322Abstract Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls. There was suppression of antigen presentation but upregulation of inflammatory and viral mRNA translation associated pathways in Symptomatic as compared with Asymptomatic cases. In severe COVID-19, CD177 a neutrophil marker, was upregulated while interferon stimulated genes (ISGs) were downregulated. Asymptomatic COVID-19 cases displayed upregulation of ISGs and humoral response genes with downregulation of ICAM3 and TLR8. Compared across the COVID-19 disease spectrum, we found type I interferon (IFN) responses to be significantly upregulated (IFNAR2, IRF2BP1, IRF4, MAVS, SAMHD1, TRIM1), or downregulated (SOCS3, IRF2BP2, IRF2BPL) in Asymptomatic as compared with mild and severe COVID-19, with the dysregulation of an increasing number of ISGs associated with progressive disease. These data suggest that initial early responses against SARS-CoV-2 may be effectively controlled by ISGs. Therefore, we hypothesize that treatment with type I interferons in the early stage of COVID-19 may limit disease progression by limiting SARS-CoV-2 in the host.Kiran Iqbal MasoodMaliha YameenJaveria AshrafSaba ShahidSyed Faisal MahmoodAsghar NasirNosheen NasirBushra JamilNajia Karim GhanchiIffat KhanumSafina Abdul RazzakAkbar KanjiRabia HussainMartin E. RottenbergZahra HasanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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Medicine R Science Q Kiran Iqbal Masood Maliha Yameen Javeria Ashraf Saba Shahid Syed Faisal Mahmood Asghar Nasir Nosheen Nasir Bushra Jamil Najia Karim Ghanchi Iffat Khanum Safina Abdul Razzak Akbar Kanji Rabia Hussain Martin E. Rottenberg Zahra Hasan Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome |
| description |
Abstract Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls. There was suppression of antigen presentation but upregulation of inflammatory and viral mRNA translation associated pathways in Symptomatic as compared with Asymptomatic cases. In severe COVID-19, CD177 a neutrophil marker, was upregulated while interferon stimulated genes (ISGs) were downregulated. Asymptomatic COVID-19 cases displayed upregulation of ISGs and humoral response genes with downregulation of ICAM3 and TLR8. Compared across the COVID-19 disease spectrum, we found type I interferon (IFN) responses to be significantly upregulated (IFNAR2, IRF2BP1, IRF4, MAVS, SAMHD1, TRIM1), or downregulated (SOCS3, IRF2BP2, IRF2BPL) in Asymptomatic as compared with mild and severe COVID-19, with the dysregulation of an increasing number of ISGs associated with progressive disease. These data suggest that initial early responses against SARS-CoV-2 may be effectively controlled by ISGs. Therefore, we hypothesize that treatment with type I interferons in the early stage of COVID-19 may limit disease progression by limiting SARS-CoV-2 in the host. |
| format |
article |
| author |
Kiran Iqbal Masood Maliha Yameen Javeria Ashraf Saba Shahid Syed Faisal Mahmood Asghar Nasir Nosheen Nasir Bushra Jamil Najia Karim Ghanchi Iffat Khanum Safina Abdul Razzak Akbar Kanji Rabia Hussain Martin E. Rottenberg Zahra Hasan |
| author_facet |
Kiran Iqbal Masood Maliha Yameen Javeria Ashraf Saba Shahid Syed Faisal Mahmood Asghar Nasir Nosheen Nasir Bushra Jamil Najia Karim Ghanchi Iffat Khanum Safina Abdul Razzak Akbar Kanji Rabia Hussain Martin E. Rottenberg Zahra Hasan |
| author_sort |
Kiran Iqbal Masood |
| title |
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome |
| title_short |
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome |
| title_full |
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome |
| title_fullStr |
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome |
| title_full_unstemmed |
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome |
| title_sort |
upregulated type i interferon responses in asymptomatic covid-19 infection are associated with improved clinical outcome |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/48388a72aa544be0b4f9b09adc2f6ea2 |
| work_keys_str_mv |
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