Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease

Abstract Purpose: To quantify the microvasculature density of the optic nerve head (ONH) using optical coherence tomography angiography (OCTA) analysis in patients recovered from Coronavirus Disease 2019 (COVID-19). Methods: In a comparative cross-sectional, observational study, patients recovered f...

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Autores principales:	Mojtaba Abrishami, Ramin Daneshvar, Zahra Emamverdian, Nasser Shoeibi, Shima Sedighi, Talieh Saeidi Rezvani, Neda Saeedian, Saeid Eslami
Formato:	article
Lenguaje:	EN
Publicado:	Knowledge E 2021
Materias:	coronavirus disease 2019 (covid-19) optic nerve head optical coherence tomography angiography (octa) radial peripapillary capillary network severe acute respiratory syndrome corona virus 2 (sars-cov-2) Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4838b828dbe340a7a65b141ec4ef07ee
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spelling	oai:doaj.org-article:4838b828dbe340a7a65b141ec4ef07ee2021-11-09T08:05:35ZOptic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease2008-20102008-322X10.18502/jovr.v16i4.9749https://doaj.org/article/4838b828dbe340a7a65b141ec4ef07ee2021-10-01T00:00:00Zhttps://doi.org/10.18502/jovr.v16i4.9749https://doaj.org/toc/2008-2010https://doaj.org/toc/2008-322XAbstract Purpose: To quantify the microvasculature density of the optic nerve head (ONH) using optical coherence tomography angiography (OCTA) analysis in patients recovered from Coronavirus Disease 2019 (COVID-19). Methods: In a comparative cross-sectional, observational study, patients recovered from COVID-19 whose initial diagnosis was confirmed by a rRT-PCR of a nasopharyngeal sample were included in this study. OCTA of ONH was performed in included patients and normal controls. Vascular density (VD) of the all vessels (AV) and small vessels (SV) inside the disc and radial peripapillary capillary (RPC) network density were measured in COVID-19 recovered patients and compared with similar parameters in an age-matched group of normal controls. Results: Twenty-five COVID-19 patients and twenty-two age-matched normal controls were enrolled in the study and one eye per participant was evaluated. The mean whole image SV VD in the COVID-19 group (49.31 ± 1.93) was not statistically significantly different from that in the control group (49.94 ± . 2.22; P = 0.308). A decrease in RPC VD was found in all AV and SV VD measured, which became statistically significant in whole peripapillary SV VD, peripapillary inferior nasal SV VD, peripapillary inferior temporal SV VD, peripapillary superior nasal SV VD, and grid-based AV VD inferior sector (P < 0.05). Inside disc SV VD in the COVID-19 group (49.43 ± 4.96) was higher than in the control group (45.46 ± 6.22) which was statistically significant (P = 0.021). Conclusion: Unremarkable decrease was found in ONH microvasculature in patients who had recovered from COVID-19. These patients may be at risk of ONH vascular complications. Increase in inner disc SV VD may be an indicator of ONH hyperemia and edema.Mojtaba AbrishamiRamin DaneshvarZahra EmamverdianNasser ShoeibiShima SedighiTalieh Saeidi RezvaniNeda SaeedianSaeid EslamiKnowledge Earticlecoronavirus disease 2019 (covid-19)optic nerve headoptical coherence tomography angiography (octa)radial peripapillary capillary networksevere acute respiratory syndrome corona virus 2 (sars-cov-2)OphthalmologyRE1-994ENJournal of Ophthalmic & Vision Research, Vol 16, Iss 4, Pp 592-601 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronavirus disease 2019 (covid-19) optic nerve head optical coherence tomography angiography (octa) radial peripapillary capillary network severe acute respiratory syndrome corona virus 2 (sars-cov-2) Ophthalmology RE1-994
spellingShingle	coronavirus disease 2019 (covid-19) optic nerve head optical coherence tomography angiography (octa) radial peripapillary capillary network severe acute respiratory syndrome corona virus 2 (sars-cov-2) Ophthalmology RE1-994 Mojtaba Abrishami Ramin Daneshvar Zahra Emamverdian Nasser Shoeibi Shima Sedighi Talieh Saeidi Rezvani Neda Saeedian Saeid Eslami Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease
description	Abstract Purpose: To quantify the microvasculature density of the optic nerve head (ONH) using optical coherence tomography angiography (OCTA) analysis in patients recovered from Coronavirus Disease 2019 (COVID-19). Methods: In a comparative cross-sectional, observational study, patients recovered from COVID-19 whose initial diagnosis was confirmed by a rRT-PCR of a nasopharyngeal sample were included in this study. OCTA of ONH was performed in included patients and normal controls. Vascular density (VD) of the all vessels (AV) and small vessels (SV) inside the disc and radial peripapillary capillary (RPC) network density were measured in COVID-19 recovered patients and compared with similar parameters in an age-matched group of normal controls. Results: Twenty-five COVID-19 patients and twenty-two age-matched normal controls were enrolled in the study and one eye per participant was evaluated. The mean whole image SV VD in the COVID-19 group (49.31 ± 1.93) was not statistically significantly different from that in the control group (49.94 ± . 2.22; P = 0.308). A decrease in RPC VD was found in all AV and SV VD measured, which became statistically significant in whole peripapillary SV VD, peripapillary inferior nasal SV VD, peripapillary inferior temporal SV VD, peripapillary superior nasal SV VD, and grid-based AV VD inferior sector (P < 0.05). Inside disc SV VD in the COVID-19 group (49.43 ± 4.96) was higher than in the control group (45.46 ± 6.22) which was statistically significant (P = 0.021). Conclusion: Unremarkable decrease was found in ONH microvasculature in patients who had recovered from COVID-19. These patients may be at risk of ONH vascular complications. Increase in inner disc SV VD may be an indicator of ONH hyperemia and edema.
format	article
author	Mojtaba Abrishami Ramin Daneshvar Zahra Emamverdian Nasser Shoeibi Shima Sedighi Talieh Saeidi Rezvani Neda Saeedian Saeid Eslami
author_facet	Mojtaba Abrishami Ramin Daneshvar Zahra Emamverdian Nasser Shoeibi Shima Sedighi Talieh Saeidi Rezvani Neda Saeedian Saeid Eslami
author_sort	Mojtaba Abrishami
title	Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease
title_short	Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease
title_full	Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease
title_fullStr	Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease
title_full_unstemmed	Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease
title_sort	optic nerve head optical coherence tomography angiography findings after coronavirus disease
publisher	Knowledge E
publishDate	2021
url	https://doaj.org/article/4838b828dbe340a7a65b141ec4ef07ee
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Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease

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