CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy
Activation of the adenosine receptor A2AR is associated with suppression of T cell function in the tumor microenvironment. To overcome immunosuppression, here the authors show that CRISPR/Cas9 mediated deletion of A2AR enhances CAR T cell effector functions without altering memory or persistence pro...
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/483b1c1b715b445cad3cbef377ef8466 |
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oai:doaj.org-article:483b1c1b715b445cad3cbef377ef84662021-12-02T14:47:28ZCRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy10.1038/s41467-021-23331-52041-1723https://doaj.org/article/483b1c1b715b445cad3cbef377ef84662021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23331-5https://doaj.org/toc/2041-1723Activation of the adenosine receptor A2AR is associated with suppression of T cell function in the tumor microenvironment. To overcome immunosuppression, here the authors show that CRISPR/Cas9 mediated deletion of A2AR enhances CAR T cell effector functions without altering memory or persistence properties, improving CAR-T mediated tumor control in pre-clinical models.Lauren GiuffridaKevin SekMelissa A. HendersonJunyun LaiAmanda X. Y. ChenDeborah MeyranKirsten L. ToddEmma V. PetleySherly MardianaChristina MølckGregory D. StewartBenjamin J. SolomonIan A. ParishPaul J. NeesonSimon J. HarrisonLev M. KatsImran G. HousePhillip K. DarcyPaul A. BeavisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lauren Giuffrida Kevin Sek Melissa A. Henderson Junyun Lai Amanda X. Y. Chen Deborah Meyran Kirsten L. Todd Emma V. Petley Sherly Mardiana Christina Mølck Gregory D. Stewart Benjamin J. Solomon Ian A. Parish Paul J. Neeson Simon J. Harrison Lev M. Kats Imran G. House Phillip K. Darcy Paul A. Beavis CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy |
| description |
Activation of the adenosine receptor A2AR is associated with suppression of T cell function in the tumor microenvironment. To overcome immunosuppression, here the authors show that CRISPR/Cas9 mediated deletion of A2AR enhances CAR T cell effector functions without altering memory or persistence properties, improving CAR-T mediated tumor control in pre-clinical models. |
| format |
article |
| author |
Lauren Giuffrida Kevin Sek Melissa A. Henderson Junyun Lai Amanda X. Y. Chen Deborah Meyran Kirsten L. Todd Emma V. Petley Sherly Mardiana Christina Mølck Gregory D. Stewart Benjamin J. Solomon Ian A. Parish Paul J. Neeson Simon J. Harrison Lev M. Kats Imran G. House Phillip K. Darcy Paul A. Beavis |
| author_facet |
Lauren Giuffrida Kevin Sek Melissa A. Henderson Junyun Lai Amanda X. Y. Chen Deborah Meyran Kirsten L. Todd Emma V. Petley Sherly Mardiana Christina Mølck Gregory D. Stewart Benjamin J. Solomon Ian A. Parish Paul J. Neeson Simon J. Harrison Lev M. Kats Imran G. House Phillip K. Darcy Paul A. Beavis |
| author_sort |
Lauren Giuffrida |
| title |
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy |
| title_short |
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy |
| title_full |
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy |
| title_fullStr |
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy |
| title_full_unstemmed |
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy |
| title_sort |
crispr/cas9 mediated deletion of the adenosine a2a receptor enhances car t cell efficacy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/483b1c1b715b445cad3cbef377ef8466 |
| work_keys_str_mv |
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1718389506920415232 |