The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience

Abstract Background Thalassemia is the most prevalent single-gene disorder. Myocardial and hepatic iron depositions lead to complications and eventually death. We aimed to assess the diagnostic efficacy of magnetic resonance imaging T2* (MRI T2*) in quantifying iron overload in liver and heart in tr...

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Autores principales:	Ashraf M. El Sherif, Ahmed S. Ibrahim, Mohamed A. Elsayed, Ahmed S. Abdelhakim, Ahlam M. Ismail
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	TDT MRI T2* Iron overload Liver Heart Children Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/483b49954cc54a1b83b05fb3dab834a0
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spelling	oai:doaj.org-article:483b49954cc54a1b83b05fb3dab834a02021-11-08T10:57:39ZThe impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience10.1186/s43055-021-00645-42090-4762https://doaj.org/article/483b49954cc54a1b83b05fb3dab834a02021-11-01T00:00:00Zhttps://doi.org/10.1186/s43055-021-00645-4https://doaj.org/toc/2090-4762Abstract Background Thalassemia is the most prevalent single-gene disorder. Myocardial and hepatic iron depositions lead to complications and eventually death. We aimed to assess the diagnostic efficacy of magnetic resonance imaging T2* (MRI T2) in quantifying iron overload in liver and heart in transfusion-dependent B-thalassemia major (TDT) children. Methods Prospective clinical study was carried on sixty children diagnosed with TDT. All of them underwent laboratory investigations, including CBC, serum iron, and ferritin levels. MRI T2 of the heart and liver was carried out to measure the iron overload and estimate the left ventricular ejection fraction (LVEF). Results Thirty-eight males and 22 females with TDT with a mean age of 13.23 years were included. Twenty cases (33.3%) had severe liver iron overload, while 36 (60%) had normal cardiac iron. There was a moderate significant negative association between hepatic and cardiac iron deposition (P = 0.03). All cases with severe cardiac iron overload had impaired LVEF below 56%. A non-significant positive association was noticed between cardiac iron deposition and LVEF in T2* (P = 0.08). A moderate negative significant association was detected between hepatic iron deposition and serum ferritin, while a fair negative significant association was found between serum ferritin and cardiac iron deposition with P values of 0.04 and 0.02, respectively. Conclusion MRI T2* is the gold standard for monitoring and follow-up of iron overload in the heart and liver. It should be routinely performed in all TDT children as liver iron, and serum ferritin do not reflect cardiac iron overload.Ashraf M. El SherifAhmed S. IbrahimMohamed A. ElsayedAhmed S. AbdelhakimAhlam M. IsmailSpringerOpenarticleTDTMRI T2*Iron overloadLiverHeartChildrenMedical physics. Medical radiology. Nuclear medicineR895-920ENThe Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TDT MRI T2* Iron overload Liver Heart Children Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	TDT MRI T2* Iron overload Liver Heart Children Medical physics. Medical radiology. Nuclear medicine R895-920 Ashraf M. El Sherif Ahmed S. Ibrahim Mohamed A. Elsayed Ahmed S. Abdelhakim Ahlam M. Ismail The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience
description	Abstract Background Thalassemia is the most prevalent single-gene disorder. Myocardial and hepatic iron depositions lead to complications and eventually death. We aimed to assess the diagnostic efficacy of magnetic resonance imaging T2* (MRI T2) in quantifying iron overload in liver and heart in transfusion-dependent B-thalassemia major (TDT) children. Methods Prospective clinical study was carried on sixty children diagnosed with TDT. All of them underwent laboratory investigations, including CBC, serum iron, and ferritin levels. MRI T2 of the heart and liver was carried out to measure the iron overload and estimate the left ventricular ejection fraction (LVEF). Results Thirty-eight males and 22 females with TDT with a mean age of 13.23 years were included. Twenty cases (33.3%) had severe liver iron overload, while 36 (60%) had normal cardiac iron. There was a moderate significant negative association between hepatic and cardiac iron deposition (P = 0.03). All cases with severe cardiac iron overload had impaired LVEF below 56%. A non-significant positive association was noticed between cardiac iron deposition and LVEF in T2* (P = 0.08). A moderate negative significant association was detected between hepatic iron deposition and serum ferritin, while a fair negative significant association was found between serum ferritin and cardiac iron deposition with P values of 0.04 and 0.02, respectively. Conclusion MRI T2* is the gold standard for monitoring and follow-up of iron overload in the heart and liver. It should be routinely performed in all TDT children as liver iron, and serum ferritin do not reflect cardiac iron overload.
format	article
author	Ashraf M. El Sherif Ahmed S. Ibrahim Mohamed A. Elsayed Ahmed S. Abdelhakim Ahlam M. Ismail
author_facet	Ashraf M. El Sherif Ahmed S. Ibrahim Mohamed A. Elsayed Ahmed S. Abdelhakim Ahlam M. Ismail
author_sort	Ashraf M. El Sherif
title	The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience
title_short	The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience
title_full	The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience
title_fullStr	The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience
title_full_unstemmed	The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience
title_sort	impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: minia experience
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/483b49954cc54a1b83b05fb3dab834a0
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The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience

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