Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum

Eosinophils are typically a minority population of circulating granulocytes being released from the bone-marrow as terminally differentiated cells. Besides their function in the defense against parasites and in promoting allergic airway inflammation, regulatory functions have now been attributed to...

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Autores principales:	Sjoerd T. T. Schetters, Martijn J. Schuijs
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	eosinophils immunology asthma lung allergic airway inflammation innate immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/483cb85f53464d408b3e9cbd89adb5a6
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id	oai:doaj.org-article:483cb85f53464d408b3e9cbd89adb5a6
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spelling	oai:doaj.org-article:483cb85f53464d408b3e9cbd89adb5a62021-11-15T06:12:08ZPulmonary Eosinophils at the Center of the Allergic Space-Time Continuum1664-322410.3389/fimmu.2021.772004https://doaj.org/article/483cb85f53464d408b3e9cbd89adb5a62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.772004/fullhttps://doaj.org/toc/1664-3224Eosinophils are typically a minority population of circulating granulocytes being released from the bone-marrow as terminally differentiated cells. Besides their function in the defense against parasites and in promoting allergic airway inflammation, regulatory functions have now been attributed to eosinophils in various organs. Although eosinophils are involved in the inflammatory response to allergens, it remains unclear whether they are drivers of the asthma pathology or merely recruited effector cells. Recent findings highlight the homeostatic and pro-resolving capacity of eosinophils and raise the question at what point in time their function is regulated. Similarly, eosinophils from different physical locations display phenotypic and functional diversity. However, it remains unclear whether eosinophil plasticity remains as they develop and travel from the bone marrow to the tissue, in homeostasis or during inflammation. In the tissue, eosinophils of different ages and origin along the inflammatory trajectory may exhibit functional diversity as circumstances change. Herein, we outline the inflammatory time line of allergic airway inflammation from acute, late, adaptive to chronic processes. We summarize the function of the eosinophils in regards to their resident localization and time of recruitment to the lung, in all stages of the inflammatory response. In all, we argue that immunological differences in eosinophils are a function of time and space as the allergic inflammatory response is initiated and resolved.Sjoerd T. T. SchettersSjoerd T. T. SchettersMartijn J. SchuijsMartijn J. SchuijsMartijn J. SchuijsFrontiers Media S.A.articleeosinophilsimmunologyasthmalungallergic airway inflammationinnate immunityImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	eosinophils immunology asthma lung allergic airway inflammation innate immunity Immunologic diseases. Allergy RC581-607
spellingShingle	eosinophils immunology asthma lung allergic airway inflammation innate immunity Immunologic diseases. Allergy RC581-607 Sjoerd T. T. Schetters Sjoerd T. T. Schetters Martijn J. Schuijs Martijn J. Schuijs Martijn J. Schuijs Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum
description	Eosinophils are typically a minority population of circulating granulocytes being released from the bone-marrow as terminally differentiated cells. Besides their function in the defense against parasites and in promoting allergic airway inflammation, regulatory functions have now been attributed to eosinophils in various organs. Although eosinophils are involved in the inflammatory response to allergens, it remains unclear whether they are drivers of the asthma pathology or merely recruited effector cells. Recent findings highlight the homeostatic and pro-resolving capacity of eosinophils and raise the question at what point in time their function is regulated. Similarly, eosinophils from different physical locations display phenotypic and functional diversity. However, it remains unclear whether eosinophil plasticity remains as they develop and travel from the bone marrow to the tissue, in homeostasis or during inflammation. In the tissue, eosinophils of different ages and origin along the inflammatory trajectory may exhibit functional diversity as circumstances change. Herein, we outline the inflammatory time line of allergic airway inflammation from acute, late, adaptive to chronic processes. We summarize the function of the eosinophils in regards to their resident localization and time of recruitment to the lung, in all stages of the inflammatory response. In all, we argue that immunological differences in eosinophils are a function of time and space as the allergic inflammatory response is initiated and resolved.
format	article
author	Sjoerd T. T. Schetters Sjoerd T. T. Schetters Martijn J. Schuijs Martijn J. Schuijs Martijn J. Schuijs
author_facet	Sjoerd T. T. Schetters Sjoerd T. T. Schetters Martijn J. Schuijs Martijn J. Schuijs Martijn J. Schuijs
author_sort	Sjoerd T. T. Schetters
title	Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum
title_short	Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum
title_full	Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum
title_fullStr	Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum
title_full_unstemmed	Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum
title_sort	pulmonary eosinophils at the center of the allergic space-time continuum
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/483cb85f53464d408b3e9cbd89adb5a6
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Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum

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