Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure

Cerebrovascular accumulation of Aβ is a common feature of Alzheimer’s disease, though it is unclear whether mutant vascular amyloid is capable of Aβ seeding. Here, the authors show microvascular amyloid seeds are capable of driving wild-type Aβ to assemble into distinctive anti-parallel fibrillary s...

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Autores principales:	Feng Xu, Ziao Fu, Sharmila Dass, AnnMarie E. Kotarba, Judianne Davis, Steven O. Smith, William E. Van Nostrand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/483f3bd3cd8348caa0a28e98e8525ac8
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spelling	oai:doaj.org-article:483f3bd3cd8348caa0a28e98e8525ac82021-12-02T17:32:06ZCerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure10.1038/ncomms135272041-1723https://doaj.org/article/483f3bd3cd8348caa0a28e98e8525ac82016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13527https://doaj.org/toc/2041-1723Cerebrovascular accumulation of Aβ is a common feature of Alzheimer’s disease, though it is unclear whether mutant vascular amyloid is capable of Aβ seeding. Here, the authors show microvascular amyloid seeds are capable of driving wild-type Aβ to assemble into distinctive anti-parallel fibrillary structures.Feng XuZiao FuSharmila DassAnnMarie E. KotarbaJudianne DavisSteven O. SmithWilliam E. Van NostrandNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Xu Ziao Fu Sharmila Dass AnnMarie E. Kotarba Judianne Davis Steven O. Smith William E. Van Nostrand Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
description	Cerebrovascular accumulation of Aβ is a common feature of Alzheimer’s disease, though it is unclear whether mutant vascular amyloid is capable of Aβ seeding. Here, the authors show microvascular amyloid seeds are capable of driving wild-type Aβ to assemble into distinctive anti-parallel fibrillary structures.
format	article
author	Feng Xu Ziao Fu Sharmila Dass AnnMarie E. Kotarba Judianne Davis Steven O. Smith William E. Van Nostrand
author_facet	Feng Xu Ziao Fu Sharmila Dass AnnMarie E. Kotarba Judianne Davis Steven O. Smith William E. Van Nostrand
author_sort	Feng Xu
title	Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
title_short	Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
title_full	Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
title_fullStr	Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
title_full_unstemmed	Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
title_sort	cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/483f3bd3cd8348caa0a28e98e8525ac8
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Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure

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