Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure

Cerebrovascular accumulation of Aβ is a common feature of Alzheimer’s disease, though it is unclear whether mutant vascular amyloid is capable of Aβ seeding. Here, the authors show microvascular amyloid seeds are capable of driving wild-type Aβ to assemble into distinctive anti-parallel fibrillary s...

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Autores principales: Feng Xu, Ziao Fu, Sharmila Dass, AnnMarie E. Kotarba, Judianne Davis, Steven O. Smith, William E. Van Nostrand
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/483f3bd3cd8348caa0a28e98e8525ac8
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