GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

Mosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and transcription factor binding sites critical for hem...

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Autores principales:	Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4842027f92a24fc0962b7e4177ab2cdc
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spelling	oai:doaj.org-article:4842027f92a24fc0962b7e4177ab2cdc2021-12-02T14:38:45ZGWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation10.1038/s41467-019-12705-52041-1723https://doaj.org/article/4842027f92a24fc0962b7e4177ab2cdc2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12705-5https://doaj.org/toc/2041-1723Mosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and transcription factor binding sites critical for hematopoiesis.Chikashi TeraoYukihide MomozawaKazuyoshi IshigakiEiryo KawakamiMasato AkiyamaPo-Ru LohGiulio GenoveseHiroki SugishitaTazro OhtaMakoto HirataJohn R. B. PerryKoichi MatsudaYoshinori MurakamiMichiaki KuboYoichiro KamataniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chikashi Terao Yukihide Momozawa Kazuyoshi Ishigaki Eiryo Kawakami Masato Akiyama Po-Ru Loh Giulio Genovese Hiroki Sugishita Tazro Ohta Makoto Hirata John R. B. Perry Koichi Matsuda Yoshinori Murakami Michiaki Kubo Yoichiro Kamatani GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
description	Mosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and transcription factor binding sites critical for hematopoiesis.
format	article
author	Chikashi Terao Yukihide Momozawa Kazuyoshi Ishigaki Eiryo Kawakami Masato Akiyama Po-Ru Loh Giulio Genovese Hiroki Sugishita Tazro Ohta Makoto Hirata John R. B. Perry Koichi Matsuda Yoshinori Murakami Michiaki Kubo Yoichiro Kamatani
author_facet	Chikashi Terao Yukihide Momozawa Kazuyoshi Ishigaki Eiryo Kawakami Masato Akiyama Po-Ru Loh Giulio Genovese Hiroki Sugishita Tazro Ohta Makoto Hirata John R. B. Perry Koichi Matsuda Yoshinori Murakami Michiaki Kubo Yoichiro Kamatani
author_sort	Chikashi Terao
title	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_short	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_full	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_fullStr	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_full_unstemmed	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_sort	gwas of mosaic loss of chromosome y highlights genetic effects on blood cell differentiation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4842027f92a24fc0962b7e4177ab2cdc
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GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

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