GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

Mosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and transcription factor binding sites critical for hem...

Full description

Saved in:
Bibliographic Details
Main Authors: Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/4842027f92a24fc0962b7e4177ab2cdc
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/4842027f92a24fc0962b7e4177ab2cdc

Similar Items