A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity

Abstract Development has intrigued humanity since ancient times. Today, the main paradigm in developmental biology and evolutionary developmental biology (evo-devo) is the genetic program, in which development is explained by the interplay and interaction of genes, that is, by the action of gene reg...

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Autor principal:	Agustín Ostachuk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4844b9f09b4b4f7a9b61749fed11ebde
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spelling	oai:doaj.org-article:4844b9f09b4b4f7a9b61749fed11ebde2021-12-02T16:49:12ZA network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity10.1038/s41598-021-88662-12045-2322https://doaj.org/article/4844b9f09b4b4f7a9b61749fed11ebde2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88662-1https://doaj.org/toc/2045-2322Abstract Development has intrigued humanity since ancient times. Today, the main paradigm in developmental biology and evolutionary developmental biology (evo-devo) is the genetic program, in which development is explained by the interplay and interaction of genes, that is, by the action of gene regulatory networks (GRNs). However, it is not even clear that a GRN, no matter how complex, can be translated into a form. Therefore, the fundamental enigma of development still remains: how is a complex organism formed from a single cell? This question unfolded the historical drama and the dialectical tension between preformation and epigenesis. In order to shed light on these issues, I studied the development of crabs (infraorder Brachyura), as representative of the subphylum Crustacea, using network theory. The external morphology of the different phases of brachyuran metamorphosis were modeled as networks and their main characteristics analyzed. As one could expect, the parameters usually regarded as indicative of network complexity, such as modularity and hierarchy, increased during development. However, when more sophisticated complexity measures were tested, it was evidenced that whereas a group of complexity measures increased during development, another group decreased. This led to consider that two kinds of complexities were being measured. I called them intensive and extensive complexity. In view of these results, I propose that crab development involves a passage from an intensive to an extensive complexity. In other words, crab development can be interpreted as a process of unfolding of an intensive, preexistent complexity.Agustín OstachukNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agustín Ostachuk A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity
description	Abstract Development has intrigued humanity since ancient times. Today, the main paradigm in developmental biology and evolutionary developmental biology (evo-devo) is the genetic program, in which development is explained by the interplay and interaction of genes, that is, by the action of gene regulatory networks (GRNs). However, it is not even clear that a GRN, no matter how complex, can be translated into a form. Therefore, the fundamental enigma of development still remains: how is a complex organism formed from a single cell? This question unfolded the historical drama and the dialectical tension between preformation and epigenesis. In order to shed light on these issues, I studied the development of crabs (infraorder Brachyura), as representative of the subphylum Crustacea, using network theory. The external morphology of the different phases of brachyuran metamorphosis were modeled as networks and their main characteristics analyzed. As one could expect, the parameters usually regarded as indicative of network complexity, such as modularity and hierarchy, increased during development. However, when more sophisticated complexity measures were tested, it was evidenced that whereas a group of complexity measures increased during development, another group decreased. This led to consider that two kinds of complexities were being measured. I called them intensive and extensive complexity. In view of these results, I propose that crab development involves a passage from an intensive to an extensive complexity. In other words, crab development can be interpreted as a process of unfolding of an intensive, preexistent complexity.
format	article
author	Agustín Ostachuk
author_facet	Agustín Ostachuk
author_sort	Agustín Ostachuk
title	A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity
title_short	A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity
title_full	A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity
title_fullStr	A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity
title_full_unstemmed	A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity
title_sort	network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4844b9f09b4b4f7a9b61749fed11ebde
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A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity

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