Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.

<h4>Background</h4>Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Dani...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Penelope P Howards, Irva Hertz-Picciotto, Bodil H Bech, Ellen A Nohr, Anne-Marie Nybo Andersen, Charles Poole, Jørn Olsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/484a7a6429044b35bdba9637180e23d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:484a7a6429044b35bdba9637180e23d2
record_format	dspace
spelling	oai:doaj.org-article:484a7a6429044b35bdba9637180e23d22021-11-18T08:08:23ZSpontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.1932-620310.1371/journal.pone.0050372https://doaj.org/article/484a7a6429044b35bdba9637180e23d22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166844/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth Cohort.<h4>Methods</h4>Women were recruited during their first prenatal visit from 1996-2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome was determined by linking the mother's Civil Registration Number to the Medical Birth Registry and the National Hospital Discharge Register. Of 97,903 eligible pregnancies, 4,443 ended in SAB between 5 and 20 completed gestational weeks, inclusive. Letigen use was reported for 565 pregnancies. Cox regression models accounting for left truncation were fit to estimate the effect of pre-conception and early pregnancy Letigen use on SAB.<h4>Principal findings</h4>The estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8-1.6) for any periconceptional Letigen use compared to no periconceptional use.<h4>Conclusions</h4>Although Letigen has high levels of caffeine (the recommended 3 pills/day are approximately equivalent to caffeine from 6 cups of coffee), periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB.Penelope P HowardsIrva Hertz-PicciottoBodil H BechEllen A NohrAnne-Marie Nybo AndersenCharles PooleJørn OlsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50372 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Penelope P Howards Irva Hertz-Picciotto Bodil H Bech Ellen A Nohr Anne-Marie Nybo Andersen Charles Poole Jørn Olsen Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.
description	<h4>Background</h4>Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth Cohort.<h4>Methods</h4>Women were recruited during their first prenatal visit from 1996-2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome was determined by linking the mother's Civil Registration Number to the Medical Birth Registry and the National Hospital Discharge Register. Of 97,903 eligible pregnancies, 4,443 ended in SAB between 5 and 20 completed gestational weeks, inclusive. Letigen use was reported for 565 pregnancies. Cox regression models accounting for left truncation were fit to estimate the effect of pre-conception and early pregnancy Letigen use on SAB.<h4>Principal findings</h4>The estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8-1.6) for any periconceptional Letigen use compared to no periconceptional use.<h4>Conclusions</h4>Although Letigen has high levels of caffeine (the recommended 3 pills/day are approximately equivalent to caffeine from 6 cups of coffee), periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB.
format	article
author	Penelope P Howards Irva Hertz-Picciotto Bodil H Bech Ellen A Nohr Anne-Marie Nybo Andersen Charles Poole Jørn Olsen
author_facet	Penelope P Howards Irva Hertz-Picciotto Bodil H Bech Ellen A Nohr Anne-Marie Nybo Andersen Charles Poole Jørn Olsen
author_sort	Penelope P Howards
title	Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.
title_short	Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.
title_full	Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.
title_fullStr	Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.
title_full_unstemmed	Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.
title_sort	spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the danish national birth cohort.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/484a7a6429044b35bdba9637180e23d2
work_keys_str_mv	AT penelopephowards spontaneousabortionandadietdrugcontainingcaffeineandephedrineastudywithinthedanishnationalbirthcohort AT irvahertzpicciotto spontaneousabortionandadietdrugcontainingcaffeineandephedrineastudywithinthedanishnationalbirthcohort AT bodilhbech spontaneousabortionandadietdrugcontainingcaffeineandephedrineastudywithinthedanishnationalbirthcohort AT ellenanohr spontaneousabortionandadietdrugcontainingcaffeineandephedrineastudywithinthedanishnationalbirthcohort AT annemarienyboandersen spontaneousabortionandadietdrugcontainingcaffeineandephedrineastudywithinthedanishnationalbirthcohort AT charlespoole spontaneousabortionandadietdrugcontainingcaffeineandephedrineastudywithinthedanishnationalbirthcohort AT jørnolsen spontaneousabortionandadietdrugcontainingcaffeineandephedrineastudywithinthedanishnationalbirthcohort
_version_	1718422164938424320

Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.

Ejemplares similares