Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer

Francesca Savioli,1,* Subodh Seth,2,* Elizabeth Morrow,1 Julie Doughty,3 Sheila Stallard,3 Andy Malyon,4 Laszlo Romics1,5 1Academic Unit of Surgery, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK; 2Department of Breast Surgery, Forth Valley Royal Hospital, Larbert, UK; 3Department of Br...

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Autores principales:	Savioli F, Seth S, Morrow E, Doughty J, Stallard S, Malyon A, Romics L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	extreme oncoplasty therapeutic mammoplasty breast conservation therapy multifocal breast cancer multicentric breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/484bcd6b27c94f39ad11875466b6dd22
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spelling	oai:doaj.org-article:484bcd6b27c94f39ad11875466b6dd222021-12-02T14:57:35ZExtreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer1179-1314https://doaj.org/article/484bcd6b27c94f39ad11875466b6dd222021-05-01T00:00:00Zhttps://www.dovepress.com/extreme-oncoplasty-breast-conservation-in-patients-with-large-multifoc-peer-reviewed-fulltext-article-BCTThttps://doaj.org/toc/1179-1314Francesca Savioli,1,* Subodh Seth,2,* Elizabeth Morrow,1 Julie Doughty,3 Sheila Stallard,3 Andy Malyon,4 Laszlo Romics1,5 1Academic Unit of Surgery, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK; 2Department of Breast Surgery, Forth Valley Royal Hospital, Larbert, UK; 3Department of Breast Surgery, Gartnavel General Hospital, Glasgow, UK; 4Canniesburn Department of Plastic Surgery, Glasgow Royal Infirmary, Glasgow, UK; 5Department of Breast Surgery, New Victoria Hospital, Glasgow, UK*These authors contributed equally to this workCorrespondence: Francesca Savioli Email Francesca.savioli@glasgow.ac.ukIntroduction: Extreme Oncoplastic Breast Conservation Surgery (EOBCS) is offered in selected patients with multifocal or multicentric breast cancer (MFMC). Recent evidence has suggested that EOBCS may be a valuable resource for patients with MFMC who may avoid the risk associated with mastectomy in favour of the benefits of breast conservation without risking their oncological outcomes. Our study examined the practice of EOBCS in two regional breast units in Glasgow, United Kingdom.Materials and Methods: A prospectively collected database of 50 patients treated with EOBC in two breast units in Glasgow between 2007 and 2018 were evaluated, and clinical outcomes were observed.Results: Fifty patients (median age 55) underwent EOBCS, of which 43 (86%) had invasive disease. Median tumour size was 55mm (50– 90) and multifocal disease was identified in 22 (44%) patients. Nine patients (18%) were found to have positive margins and underwent a second procedure, with 6 (12%) proceeding to mastectomy. Five-year disease free survival rate was 91.5%, while cancer-specific survival was 95.7%.Conclusion: EOBCS is oncologically safe in short-term follow-up. Large scale studies are required to confirm these preliminary results, in order to offer EOBCS as a valid option to patients with advanced or multifocal breast cancer.Keywords: extreme oncoplasty, therapeutic mammoplasty, breast conservation therapy, multifocal breast cancer, multicentric breast cancerSavioli FSeth SMorrow EDoughty JStallard SMalyon ARomics LDove Medical Pressarticleextreme oncoplastytherapeutic mammoplastybreast conservation therapymultifocal breast cancermulticentric breast cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 13, Pp 353-359 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extreme oncoplasty therapeutic mammoplasty breast conservation therapy multifocal breast cancer multicentric breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	extreme oncoplasty therapeutic mammoplasty breast conservation therapy multifocal breast cancer multicentric breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Savioli F Seth S Morrow E Doughty J Stallard S Malyon A Romics L Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer
description	Francesca Savioli,1,* Subodh Seth,2,* Elizabeth Morrow,1 Julie Doughty,3 Sheila Stallard,3 Andy Malyon,4 Laszlo Romics1,5 1Academic Unit of Surgery, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK; 2Department of Breast Surgery, Forth Valley Royal Hospital, Larbert, UK; 3Department of Breast Surgery, Gartnavel General Hospital, Glasgow, UK; 4Canniesburn Department of Plastic Surgery, Glasgow Royal Infirmary, Glasgow, UK; 5Department of Breast Surgery, New Victoria Hospital, Glasgow, UK*These authors contributed equally to this workCorrespondence: Francesca Savioli Email Francesca.savioli@glasgow.ac.ukIntroduction: Extreme Oncoplastic Breast Conservation Surgery (EOBCS) is offered in selected patients with multifocal or multicentric breast cancer (MFMC). Recent evidence has suggested that EOBCS may be a valuable resource for patients with MFMC who may avoid the risk associated with mastectomy in favour of the benefits of breast conservation without risking their oncological outcomes. Our study examined the practice of EOBCS in two regional breast units in Glasgow, United Kingdom.Materials and Methods: A prospectively collected database of 50 patients treated with EOBC in two breast units in Glasgow between 2007 and 2018 were evaluated, and clinical outcomes were observed.Results: Fifty patients (median age 55) underwent EOBCS, of which 43 (86%) had invasive disease. Median tumour size was 55mm (50– 90) and multifocal disease was identified in 22 (44%) patients. Nine patients (18%) were found to have positive margins and underwent a second procedure, with 6 (12%) proceeding to mastectomy. Five-year disease free survival rate was 91.5%, while cancer-specific survival was 95.7%.Conclusion: EOBCS is oncologically safe in short-term follow-up. Large scale studies are required to confirm these preliminary results, in order to offer EOBCS as a valid option to patients with advanced or multifocal breast cancer.Keywords: extreme oncoplasty, therapeutic mammoplasty, breast conservation therapy, multifocal breast cancer, multicentric breast cancer
format	article
author	Savioli F Seth S Morrow E Doughty J Stallard S Malyon A Romics L
author_facet	Savioli F Seth S Morrow E Doughty J Stallard S Malyon A Romics L
author_sort	Savioli F
title	Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer
title_short	Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer
title_full	Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer
title_fullStr	Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer
title_full_unstemmed	Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer
title_sort	extreme oncoplasty: breast conservation in patients with large, multifocal, and multicentric breast cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/484bcd6b27c94f39ad11875466b6dd22
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Extreme Oncoplasty: Breast Conservation in Patients with Large, Multifocal, and Multicentric Breast Cancer

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