CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling

CCN1 is a matricellular protein with a variety of functions, including an effect on wound healing and an association with inflammation. Here, the authors identify a possible mechanism by showing that CCN1 mediates the clearance of bacterial infections in mice and activates TLR signalling.

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Detalles Bibliográficos
Autores principales:	Joon-Il Jun, Lester F. Lau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/484bcf6fc0ac4f8cace309d830686ffe
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spelling	oai:doaj.org-article:484bcf6fc0ac4f8cace309d830686ffe2021-12-02T15:37:09ZCCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling10.1038/s41467-020-15075-52041-1723https://doaj.org/article/484bcf6fc0ac4f8cace309d830686ffe2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15075-5https://doaj.org/toc/2041-1723CCN1 is a matricellular protein with a variety of functions, including an effect on wound healing and an association with inflammation. Here, the authors identify a possible mechanism by showing that CCN1 mediates the clearance of bacterial infections in mice and activates TLR signalling.Joon-Il JunLester F. LauNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joon-Il Jun Lester F. Lau CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
description	CCN1 is a matricellular protein with a variety of functions, including an effect on wound healing and an association with inflammation. Here, the authors identify a possible mechanism by showing that CCN1 mediates the clearance of bacterial infections in mice and activates TLR signalling.
format	article
author	Joon-Il Jun Lester F. Lau
author_facet	Joon-Il Jun Lester F. Lau
author_sort	Joon-Il Jun
title	CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
title_short	CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
title_full	CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
title_fullStr	CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
title_full_unstemmed	CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
title_sort	ccn1 is an opsonin for bacterial clearance and a direct activator of toll-like receptor signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/484bcf6fc0ac4f8cace309d830686ffe
work_keys_str_mv	AT jooniljun ccn1isanopsoninforbacterialclearanceandadirectactivatoroftolllikereceptorsignaling AT lesterflau ccn1isanopsoninforbacterialclearanceandadirectactivatoroftolllikereceptorsignaling
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CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling

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