Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report
Vitamin B12 deficiency in children can cause megaloblastic anemia, poor growth, and increased chances of infections. It is an important reversible cause of bone marrow suppression which at the time of presentation can mimic hematological malignancy. Therefore, it should be considered as a different...
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Nepal Medical Association
2021
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oai:doaj.org-article:484f7535b00045f49b20514c8a484eb02021-11-18T19:20:10ZVitamin B12 Deficiency Resembling Acute Leukemia: A Case Report 10.31729/jnma.66000028-27151815-672Xhttps://doaj.org/article/484f7535b00045f49b20514c8a484eb02021-11-01T00:00:00Zhttp://www.jnma.com.np/jnma/index.php/jnma/article/view/6600https://doaj.org/toc/0028-2715https://doaj.org/toc/1815-672X Vitamin B12 deficiency in children can cause megaloblastic anemia, poor growth, and increased chances of infections. It is an important reversible cause of bone marrow suppression which at the time of presentation can mimic hematological malignancy. Therefore, it should be considered as a differential diagnosis in cases suspected of acute leukemia. We report a case of 14 months old child who had atypical presentation of vitamin B12 deficiency. He had chronic fever, decreased feeding and increased paleness for one year. Pancytopenia with severe anemia was present along with 19% reactive/atypical cells in peripheral blood smear suggesting acute leukemia. However, bone marrow aspiration and biopsy showed features of megaloblastic anemia. Vitamin B12 level measured was very low and treatment with cyanocobalamin caused drastic improvement in the child’s condition. Nisha SharmaSaru kunwarAnil Kumar ShresthaNepal Medical Associationarticleanemia; leukemia; pancytopenia; vitamin B12 deficiency.Medicine (General)R5-920ENJournal of Nepal Medical Association, Vol 59, Iss 243 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
anemia; leukemia; pancytopenia; vitamin B12 deficiency. Medicine (General) R5-920 |
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anemia; leukemia; pancytopenia; vitamin B12 deficiency. Medicine (General) R5-920 Nisha Sharma Saru kunwar Anil Kumar Shrestha Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report |
| description |
Vitamin B12 deficiency in children can cause megaloblastic anemia, poor growth, and increased chances of infections. It is an important reversible cause of bone marrow suppression which at the time of presentation can mimic hematological malignancy. Therefore, it should be considered as a differential diagnosis in cases suspected of acute leukemia. We report a case of 14 months old child who had atypical presentation of vitamin B12 deficiency. He had chronic fever, decreased feeding and increased paleness for one year. Pancytopenia with severe anemia was present along with 19% reactive/atypical cells in peripheral blood smear suggesting acute leukemia. However, bone marrow aspiration and biopsy showed features of megaloblastic anemia. Vitamin B12 level measured was very low and treatment with cyanocobalamin caused drastic improvement in the child’s condition.
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| format |
article |
| author |
Nisha Sharma Saru kunwar Anil Kumar Shrestha |
| author_facet |
Nisha Sharma Saru kunwar Anil Kumar Shrestha |
| author_sort |
Nisha Sharma |
| title |
Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report |
| title_short |
Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report |
| title_full |
Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report |
| title_fullStr |
Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report |
| title_full_unstemmed |
Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report |
| title_sort |
vitamin b12 deficiency resembling acute leukemia: a case report |
| publisher |
Nepal Medical Association |
| publishDate |
2021 |
| url |
https://doaj.org/article/484f7535b00045f49b20514c8a484eb0 |
| work_keys_str_mv |
AT nishasharma vitaminb12deficiencyresemblingacuteleukemiaacasereport AT sarukunwar vitaminb12deficiencyresemblingacuteleukemiaacasereport AT anilkumarshrestha vitaminb12deficiencyresemblingacuteleukemiaacasereport |
| _version_ |
1718420722695536640 |