Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms

Objective: Gastrointestinal (GI) symptoms are fairly common somatic symptoms in depressed patients. The purpose of this study was to explore the influence of concomitant GI symptoms on the fractional amplitude of low-frequency fluctuation (fALFF) patterns in patients with major depressive disorder (...

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Autores principales:	Xiaoya Fu, Huabing Li, Meiqi Yan, Jindong Chen, Feng Liu, Jingping Zhao, Wenbin Guo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	fractional amplitude low-frequency fluctuation major depressive disorder gastrointestinal symptoms functional magnet resonance imaging (fMRI) somatic symptoms Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/485493136eb443b882ba338fb147d848
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spelling	oai:doaj.org-article:485493136eb443b882ba338fb147d8482021-12-02T07:18:46ZShared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms1664-064010.3389/fpsyt.2021.744898https://doaj.org/article/485493136eb443b882ba338fb147d8482021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.744898/fullhttps://doaj.org/toc/1664-0640Objective: Gastrointestinal (GI) symptoms are fairly common somatic symptoms in depressed patients. The purpose of this study was to explore the influence of concomitant GI symptoms on the fractional amplitude of low-frequency fluctuation (fALFF) patterns in patients with major depressive disorder (MDD) and investigate the connection between aberrant fALFF and clinical characteristics.Methods: This study included 35 MDD patients with GI symptoms (GI-MDD patients), 17 MDD patients without GI symptoms (nGI-MDD patients), and 28 healthy controls (HCs). The fALFF method was used to analyze the resting-state functional magnetic resonance imaging data. Correlation analysis and pattern classification were employed to investigate the relationship of the fALFF patterns with the clinical characteristics of patients.Results: GI-MDD patients exhibited higher scores in the HRSD-17 and suffered more severe insomnia, anxiety/somatization, and weight loss than nGI-MDD patients. GI-MDD patients showed higher fALFF in the right superior frontal gyrus (SFG)/middle frontal gyrus (MFG) and lower fALFF in the left superior medial prefrontal cortex (MPFC) compared with nGI-MDD patients. A combination of the fALFF values of these two clusters could be applied to discriminate GI-MDD patients from nGI-MDD patients, with accuracy, sensitivity, and specificity of 86.54, 94.29, and 70.59%, respectively.Conclusion: GI-MDD patients showed more severe depressive symptoms. Increased fALFF in the right SFG/MFG and decreased fALFF in the left superior MPFC might be distinctive neurobiological features of MDD patients with GI symptoms.Xiaoya FuHuabing LiMeiqi YanJindong ChenFeng LiuJingping ZhaoWenbin GuoWenbin GuoFrontiers Media S.A.articlefractional amplitude low-frequency fluctuationmajor depressive disordergastrointestinal symptomsfunctional magnet resonance imaging (fMRI)somatic symptomsPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fractional amplitude low-frequency fluctuation major depressive disorder gastrointestinal symptoms functional magnet resonance imaging (fMRI) somatic symptoms Psychiatry RC435-571
spellingShingle	fractional amplitude low-frequency fluctuation major depressive disorder gastrointestinal symptoms functional magnet resonance imaging (fMRI) somatic symptoms Psychiatry RC435-571 Xiaoya Fu Huabing Li Meiqi Yan Jindong Chen Feng Liu Jingping Zhao Wenbin Guo Wenbin Guo Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms
description	Objective: Gastrointestinal (GI) symptoms are fairly common somatic symptoms in depressed patients. The purpose of this study was to explore the influence of concomitant GI symptoms on the fractional amplitude of low-frequency fluctuation (fALFF) patterns in patients with major depressive disorder (MDD) and investigate the connection between aberrant fALFF and clinical characteristics.Methods: This study included 35 MDD patients with GI symptoms (GI-MDD patients), 17 MDD patients without GI symptoms (nGI-MDD patients), and 28 healthy controls (HCs). The fALFF method was used to analyze the resting-state functional magnetic resonance imaging data. Correlation analysis and pattern classification were employed to investigate the relationship of the fALFF patterns with the clinical characteristics of patients.Results: GI-MDD patients exhibited higher scores in the HRSD-17 and suffered more severe insomnia, anxiety/somatization, and weight loss than nGI-MDD patients. GI-MDD patients showed higher fALFF in the right superior frontal gyrus (SFG)/middle frontal gyrus (MFG) and lower fALFF in the left superior medial prefrontal cortex (MPFC) compared with nGI-MDD patients. A combination of the fALFF values of these two clusters could be applied to discriminate GI-MDD patients from nGI-MDD patients, with accuracy, sensitivity, and specificity of 86.54, 94.29, and 70.59%, respectively.Conclusion: GI-MDD patients showed more severe depressive symptoms. Increased fALFF in the right SFG/MFG and decreased fALFF in the left superior MPFC might be distinctive neurobiological features of MDD patients with GI symptoms.
format	article
author	Xiaoya Fu Huabing Li Meiqi Yan Jindong Chen Feng Liu Jingping Zhao Wenbin Guo Wenbin Guo
author_facet	Xiaoya Fu Huabing Li Meiqi Yan Jindong Chen Feng Liu Jingping Zhao Wenbin Guo Wenbin Guo
author_sort	Xiaoya Fu
title	Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms
title_short	Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms
title_full	Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms
title_fullStr	Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms
title_full_unstemmed	Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms
title_sort	shared and distinct fractional amplitude of low-frequency fluctuation patterns in major depressive disorders with and without gastrointestinal symptoms
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/485493136eb443b882ba338fb147d848
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Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms

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