ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia

While the role of ASLX1 in haematopoiesis and leukaemia has been heavily studied, the role of ASLX2 is unclear. Here the authors show that ASLX2 is required for normal haematopoietic stem cell self-renewal whereas Asxl2 loss promotes leukemogenesis, thus explaining the frequently observed mutations...

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Autores principales:	Jean-Baptiste Micol, Alessandro Pastore, Daichi Inoue, Nicolas Duployez, Eunhee Kim, Stanley Chun-Wei Lee, Benjamin H. Durham, Young Rock Chung, Hana Cho, Xiao Jing Zhang, Akihide Yoshimi, Andrei Krivtsov, Richard Koche, Eric Solary, Amit Sinha, Claude Preudhomme, Omar Abdel-Wahab
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4858a0bedd1541a2a819f03ad5087413
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spelling	oai:doaj.org-article:4858a0bedd1541a2a819f03ad50874132021-12-02T15:38:39ZASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia10.1038/ncomms154292041-1723https://doaj.org/article/4858a0bedd1541a2a819f03ad50874132017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15429https://doaj.org/toc/2041-1723While the role of ASLX1 in haematopoiesis and leukaemia has been heavily studied, the role of ASLX2 is unclear. Here the authors show that ASLX2 is required for normal haematopoietic stem cell self-renewal whereas Asxl2 loss promotes leukemogenesis, thus explaining the frequently observed mutations in AML patientsJean-Baptiste MicolAlessandro PastoreDaichi InoueNicolas DuployezEunhee KimStanley Chun-Wei LeeBenjamin H. DurhamYoung Rock ChungHana ChoXiao Jing ZhangAkihide YoshimiAndrei KrivtsovRichard KocheEric SolaryAmit SinhaClaude PreudhommeOmar Abdel-WahabNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jean-Baptiste Micol Alessandro Pastore Daichi Inoue Nicolas Duployez Eunhee Kim Stanley Chun-Wei Lee Benjamin H. Durham Young Rock Chung Hana Cho Xiao Jing Zhang Akihide Yoshimi Andrei Krivtsov Richard Koche Eric Solary Amit Sinha Claude Preudhomme Omar Abdel-Wahab ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
description	While the role of ASLX1 in haematopoiesis and leukaemia has been heavily studied, the role of ASLX2 is unclear. Here the authors show that ASLX2 is required for normal haematopoietic stem cell self-renewal whereas Asxl2 loss promotes leukemogenesis, thus explaining the frequently observed mutations in AML patients
format	article
author	Jean-Baptiste Micol Alessandro Pastore Daichi Inoue Nicolas Duployez Eunhee Kim Stanley Chun-Wei Lee Benjamin H. Durham Young Rock Chung Hana Cho Xiao Jing Zhang Akihide Yoshimi Andrei Krivtsov Richard Koche Eric Solary Amit Sinha Claude Preudhomme Omar Abdel-Wahab
author_facet	Jean-Baptiste Micol Alessandro Pastore Daichi Inoue Nicolas Duployez Eunhee Kim Stanley Chun-Wei Lee Benjamin H. Durham Young Rock Chung Hana Cho Xiao Jing Zhang Akihide Yoshimi Andrei Krivtsov Richard Koche Eric Solary Amit Sinha Claude Preudhomme Omar Abdel-Wahab
author_sort	Jean-Baptiste Micol
title	ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
title_short	ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
title_full	ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
title_fullStr	ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
title_full_unstemmed	ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
title_sort	asxl2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4858a0bedd1541a2a819f03ad5087413
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ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia

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