LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children
Zhiyuan Wu,1,* Yongqin Yu,1,* Lanyan Fu,2 Hanran Mai,2 Li Huang,1 Di Che,2 Jianping Tao,1 Xiaoqiong Gu2– 4 1Department of Pediatric Intensive Care Unit, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of C...
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Dove Medical Press
2020
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oai:doaj.org-article:486151d5d6ad43a3b50b9d7ac4705cb52021-12-02T15:12:04ZLncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children1178-7031https://doaj.org/article/486151d5d6ad43a3b50b9d7ac4705cb52020-12-01T00:00:00Zhttps://www.dovepress.com/lncrna-sox2ot-rs9839776-polymorphism-reduces-sepsis-susceptibility-in--peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Zhiyuan Wu,1,* Yongqin Yu,1,* Lanyan Fu,2 Hanran Mai,2 Li Huang,1 Di Che,2 Jianping Tao,1 Xiaoqiong Gu2– 4 1Department of Pediatric Intensive Care Unit, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of China; 2Department of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of China; 3Department of Blood Transfusion, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of China; 4Department of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoqiong Gu; Jianping Tao Email guxiaoqiong@gwcmc.org; golou6354@163.comBackground: Sepsis in children is one of the main causes of death in pediatric intensive care units (PICUs); however, the pathogenesis of sepsis is not fully clear. Previous studies revealed that many genetic variations were related to sepsis susceptibility. A long non-coding RNA SOX2 overlapping transcript (SOX2OT) may play a role in mitochondrial homeostasis and antioxidative activity, but the relationship between the lncRNA SOX2OT polymorphism and sepsis susceptibility has not been reported.Methods: In this study, 474 pediatric sepsis patients and 678 healthy controls were recruited from southern China. After genotyping, the strength of the associations was evaluated through odds ratios (ORs) and 95% confidence intervals (CIs).Results: The SOX2OT rs9839776 T allele was associated with decreased susceptibility to sepsis in southern Chinese children (TT/CT vs CC adjusted OR = 0.778, 95% CI = 0.610– 0.992; P = 0.0431). Moreover, the difference in susceptibility was greater in children of age > 60 months (adjusted OR = 0.458, 95% CI = 0.234– 0.896; P = 0.0225), survivors (adjusted OR = 0.758, 95% CI = 0.585– 0.972; P = 0.0358), males (adjusted OR = 0.655, 95% CI = 0.479– 0.894; P = 0.0077) and the sepsis subgroup (adjusted OR = 0.548, 95% CI = 0.343– 0.876; P = 0.0120).Conclusion: The rs9839776 T allele may contribute to decreased sepsis risk in Chinese children. Future studies with a larger sample size are needed to verify these results.Keywords: sepsis, SOX2OT, rs9839776, susceptibility, polymorphismWu ZYu YFu LMai HHuang LChe DTao JGu XDove Medical Pressarticlesepsissox2otrs9839776susceptibilitypolymorphismPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 1095-1101 (2020) |
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sepsis sox2ot rs9839776 susceptibility polymorphism Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
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sepsis sox2ot rs9839776 susceptibility polymorphism Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Wu Z Yu Y Fu L Mai H Huang L Che D Tao J Gu X LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children |
| description |
Zhiyuan Wu,1,* Yongqin Yu,1,* Lanyan Fu,2 Hanran Mai,2 Li Huang,1 Di Che,2 Jianping Tao,1 Xiaoqiong Gu2– 4 1Department of Pediatric Intensive Care Unit, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of China; 2Department of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of China; 3Department of Blood Transfusion, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of China; 4Department of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoqiong Gu; Jianping Tao Email guxiaoqiong@gwcmc.org; golou6354@163.comBackground: Sepsis in children is one of the main causes of death in pediatric intensive care units (PICUs); however, the pathogenesis of sepsis is not fully clear. Previous studies revealed that many genetic variations were related to sepsis susceptibility. A long non-coding RNA SOX2 overlapping transcript (SOX2OT) may play a role in mitochondrial homeostasis and antioxidative activity, but the relationship between the lncRNA SOX2OT polymorphism and sepsis susceptibility has not been reported.Methods: In this study, 474 pediatric sepsis patients and 678 healthy controls were recruited from southern China. After genotyping, the strength of the associations was evaluated through odds ratios (ORs) and 95% confidence intervals (CIs).Results: The SOX2OT rs9839776 T allele was associated with decreased susceptibility to sepsis in southern Chinese children (TT/CT vs CC adjusted OR = 0.778, 95% CI = 0.610– 0.992; P = 0.0431). Moreover, the difference in susceptibility was greater in children of age > 60 months (adjusted OR = 0.458, 95% CI = 0.234– 0.896; P = 0.0225), survivors (adjusted OR = 0.758, 95% CI = 0.585– 0.972; P = 0.0358), males (adjusted OR = 0.655, 95% CI = 0.479– 0.894; P = 0.0077) and the sepsis subgroup (adjusted OR = 0.548, 95% CI = 0.343– 0.876; P = 0.0120).Conclusion: The rs9839776 T allele may contribute to decreased sepsis risk in Chinese children. Future studies with a larger sample size are needed to verify these results.Keywords: sepsis, SOX2OT, rs9839776, susceptibility, polymorphism |
| format |
article |
| author |
Wu Z Yu Y Fu L Mai H Huang L Che D Tao J Gu X |
| author_facet |
Wu Z Yu Y Fu L Mai H Huang L Che D Tao J Gu X |
| author_sort |
Wu Z |
| title |
LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children |
| title_short |
LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children |
| title_full |
LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children |
| title_fullStr |
LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children |
| title_full_unstemmed |
LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children |
| title_sort |
lncrna sox2ot rs9839776 polymorphism reduces sepsis susceptibility in southern chinese children |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/486151d5d6ad43a3b50b9d7ac4705cb5 |
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