Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability

Anis Syauqina Mohd Zaffarin,1 Shiow-Fern Ng,2 Min Hwei Ng,3 Haniza Hassan,4 Ekram Alias1 1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia; 2Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia; 3Centre for Tis...

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Autores principales:	Mohd Zaffarin AS, Ng SF, Ng MH, Hassan H, Alias E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	tocopherols tocotrienols nanoparticles drug delivery bioavailability Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/486290ada7fb4c759f34738f7db7d32b
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spelling	oai:doaj.org-article:486290ada7fb4c759f34738f7db7d32b2021-12-02T13:47:23ZPharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability1178-2013https://doaj.org/article/486290ada7fb4c759f34738f7db7d32b2020-12-01T00:00:00Zhttps://www.dovepress.com/pharmacology-and-pharmacokinetics-of-vitamin-e-nanoformulations-to-enh-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Anis Syauqina Mohd Zaffarin,1 Shiow-Fern Ng,2 Min Hwei Ng,3 Haniza Hassan,4 Ekram Alias1 1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia; 2Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia; 3Centre for Tissue Engineering and Regenerative Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, Malaysia; 4Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaCorrespondence: Ekram AliasDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, W.P., Kuala Lumpur 56000, MalaysiaTel +60 3 9145 9559Fax +60 3 9145 9546Email ekram.alias@ppukm.ukm.edu.myHaniza HassanDepartment of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, MalaysiaEmail niza.hassan@upm.edu.myAbstract: Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups, tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although vitamin E is widely known as a potent antioxidant, studies have also revealed that vitamin E possesses anti-inflammatory properties. These crucial properties of vitamin E are beneficial in various aspects of health, especially in neuroprotection and cardiovascular, skin and bone health. However, the poor bioavailability of vitamin E, especially tocotrienols, remains a great limitation for clinical applications. Recently, nanoformulations that include nanovesicles, solid-lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and polymeric nanoparticles have shown promising outcomes in improving the efficacy and bioavailability of vitamin E. This review focuses on the pharmacological properties and pharmacokinetics of vitamin E and current advances in vitamin E nanoformulations for future clinical applications. The limitations and future recommendations are also discussed in this review.Keywords: tocopherols, tocotrienols, nanoparticles, drug delivery, bioavailabilityMohd Zaffarin ASNg SFNg MHHassan HAlias EDove Medical Pressarticletocopherolstocotrienolsnanoparticlesdrug deliverybioavailabilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9961-9974 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	tocopherols tocotrienols nanoparticles drug delivery bioavailability Medicine (General) R5-920
spellingShingle	tocopherols tocotrienols nanoparticles drug delivery bioavailability Medicine (General) R5-920 Mohd Zaffarin AS Ng SF Ng MH Hassan H Alias E Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability
description	Anis Syauqina Mohd Zaffarin,1 Shiow-Fern Ng,2 Min Hwei Ng,3 Haniza Hassan,4 Ekram Alias1 1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia; 2Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia; 3Centre for Tissue Engineering and Regenerative Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, Malaysia; 4Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaCorrespondence: Ekram AliasDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, W.P., Kuala Lumpur 56000, MalaysiaTel +60 3 9145 9559Fax +60 3 9145 9546Email ekram.alias@ppukm.ukm.edu.myHaniza HassanDepartment of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, MalaysiaEmail niza.hassan@upm.edu.myAbstract: Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups, tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although vitamin E is widely known as a potent antioxidant, studies have also revealed that vitamin E possesses anti-inflammatory properties. These crucial properties of vitamin E are beneficial in various aspects of health, especially in neuroprotection and cardiovascular, skin and bone health. However, the poor bioavailability of vitamin E, especially tocotrienols, remains a great limitation for clinical applications. Recently, nanoformulations that include nanovesicles, solid-lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and polymeric nanoparticles have shown promising outcomes in improving the efficacy and bioavailability of vitamin E. This review focuses on the pharmacological properties and pharmacokinetics of vitamin E and current advances in vitamin E nanoformulations for future clinical applications. The limitations and future recommendations are also discussed in this review.Keywords: tocopherols, tocotrienols, nanoparticles, drug delivery, bioavailability
format	article
author	Mohd Zaffarin AS Ng SF Ng MH Hassan H Alias E
author_facet	Mohd Zaffarin AS Ng SF Ng MH Hassan H Alias E
author_sort	Mohd Zaffarin AS
title	Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability
title_short	Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability
title_full	Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability
title_fullStr	Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability
title_full_unstemmed	Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability
title_sort	pharmacology and pharmacokinetics of vitamin e: nanoformulations to enhance bioavailability
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/486290ada7fb4c759f34738f7db7d32b
work_keys_str_mv	AT mohdzaffarinas pharmacologyandpharmacokineticsofvitaminenanoformulationstoenhancebioavailability AT ngsf pharmacologyandpharmacokineticsofvitaminenanoformulationstoenhancebioavailability AT ngmh pharmacologyandpharmacokineticsofvitaminenanoformulationstoenhancebioavailability AT hassanh pharmacologyandpharmacokineticsofvitaminenanoformulationstoenhancebioavailability AT aliase pharmacologyandpharmacokineticsofvitaminenanoformulationstoenhancebioavailability
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Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability

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