Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea

Obstructive Sleep Apnea (OSA) is a form of sleep-disordered breathing characterized by upper airway collapse during sleep resulting in recurring arousals and desaturations. However, many aspects of this syndrome in children remain unclear. Understanding underlying pathogenic mechanisms of OSA is cri...

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Autores principales:	Ashley L. Saint-Fleur, Alexa Christophides, Prabhavathi Gummalla, Catherine Kier
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pediatric obstructive sleep apnea mechanisms upper airway critical pressure starling resistor model craniofacial Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/4866839c33824e079ddf897d8ae14ab7
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spelling	oai:doaj.org-article:4866839c33824e079ddf897d8ae14ab72021-11-25T17:14:42ZMuch Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea10.3390/children81110322227-9067https://doaj.org/article/4866839c33824e079ddf897d8ae14ab72021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/1032https://doaj.org/toc/2227-9067Obstructive Sleep Apnea (OSA) is a form of sleep-disordered breathing characterized by upper airway collapse during sleep resulting in recurring arousals and desaturations. However, many aspects of this syndrome in children remain unclear. Understanding underlying pathogenic mechanisms of OSA is critical for the development of therapeutic strategies. In this article, we review current concepts surrounding the mechanism, pathogenesis, and predisposing factors of pediatric OSA. Specifically, we discuss the biomechanical properties of the upper airway that contribute to its primary role in OSA pathogenesis and examine the anatomical and neuromuscular factors that predispose to upper airway narrowing and collapsibility.Ashley L. Saint-FleurAlexa ChristophidesPrabhavathi GummallaCatherine KierMDPI AGarticlepediatric obstructive sleep apneamechanismsupper airwaycritical pressurestarling resistor modelcraniofacialPediatricsRJ1-570ENChildren, Vol 8, Iss 1032, p 1032 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pediatric obstructive sleep apnea mechanisms upper airway critical pressure starling resistor model craniofacial Pediatrics RJ1-570
spellingShingle	pediatric obstructive sleep apnea mechanisms upper airway critical pressure starling resistor model craniofacial Pediatrics RJ1-570 Ashley L. Saint-Fleur Alexa Christophides Prabhavathi Gummalla Catherine Kier Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea
description	Obstructive Sleep Apnea (OSA) is a form of sleep-disordered breathing characterized by upper airway collapse during sleep resulting in recurring arousals and desaturations. However, many aspects of this syndrome in children remain unclear. Understanding underlying pathogenic mechanisms of OSA is critical for the development of therapeutic strategies. In this article, we review current concepts surrounding the mechanism, pathogenesis, and predisposing factors of pediatric OSA. Specifically, we discuss the biomechanical properties of the upper airway that contribute to its primary role in OSA pathogenesis and examine the anatomical and neuromuscular factors that predispose to upper airway narrowing and collapsibility.
format	article
author	Ashley L. Saint-Fleur Alexa Christophides Prabhavathi Gummalla Catherine Kier
author_facet	Ashley L. Saint-Fleur Alexa Christophides Prabhavathi Gummalla Catherine Kier
author_sort	Ashley L. Saint-Fleur
title	Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea
title_short	Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea
title_full	Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea
title_fullStr	Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea
title_full_unstemmed	Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea
title_sort	much ado about sleep: current concepts on mechanisms and predisposition to pediatric obstructive sleep apnea
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4866839c33824e079ddf897d8ae14ab7
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Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea

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