Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis

Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS, the molecular mechanisms modulating the nuclear pore function are still largely unknown. Here, authors show that genetic and pharmacological modulation of actin polymerization disrupts nuclear pore integ...

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Autores principales:	Anthony Giampetruzzi, Eric W. Danielson, Valentina Gumina, Maryangel Jeon, Sivakumar Boopathy, Robert H. Brown, Antonia Ratti, John E. Landers, Claudia Fallini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4867191c436f4c4089c528cf4fcb33b4
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spelling	oai:doaj.org-article:4867191c436f4c4089c528cf4fcb33b42021-12-02T15:35:31ZModulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis10.1038/s41467-019-11837-y2041-1723https://doaj.org/article/4867191c436f4c4089c528cf4fcb33b42019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11837-yhttps://doaj.org/toc/2041-1723Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS, the molecular mechanisms modulating the nuclear pore function are still largely unknown. Here, authors show that genetic and pharmacological modulation of actin polymerization disrupts nuclear pore integrity and can be targeted to rescue nuclear pore instability and dysfunction caused by mutant PFN1 as well as by C9ORF72 repeat expansionAnthony GiampetruzziEric W. DanielsonValentina GuminaMaryangel JeonSivakumar BoopathyRobert H. BrownAntonia RattiJohn E. LandersClaudia FalliniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anthony Giampetruzzi Eric W. Danielson Valentina Gumina Maryangel Jeon Sivakumar Boopathy Robert H. Brown Antonia Ratti John E. Landers Claudia Fallini Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
description	Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS, the molecular mechanisms modulating the nuclear pore function are still largely unknown. Here, authors show that genetic and pharmacological modulation of actin polymerization disrupts nuclear pore integrity and can be targeted to rescue nuclear pore instability and dysfunction caused by mutant PFN1 as well as by C9ORF72 repeat expansion
format	article
author	Anthony Giampetruzzi Eric W. Danielson Valentina Gumina Maryangel Jeon Sivakumar Boopathy Robert H. Brown Antonia Ratti John E. Landers Claudia Fallini
author_facet	Anthony Giampetruzzi Eric W. Danielson Valentina Gumina Maryangel Jeon Sivakumar Boopathy Robert H. Brown Antonia Ratti John E. Landers Claudia Fallini
author_sort	Anthony Giampetruzzi
title	Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
title_short	Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
title_full	Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
title_fullStr	Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
title_full_unstemmed	Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
title_sort	modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4867191c436f4c4089c528cf4fcb33b4
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_version_	1718386529228816384

Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis

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