Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination

The rare and severe adverse effects associated with coronavirus disease of 2019 (COVID-19) vaccination have been under-appreciated, resulting in many instances of inappropriate management. We describe the case of an elderly woman who developed anti-neutrophil cytoplasmic antibody-associated vasculit...

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Autores principales:	Chien-Chou Chen, Hsin-Yang Chen, Chun-Chi Lu, Shih-Hua Lin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anti-neutrophil cytoplasmic antibody (ANCA) vasculitis vaccination COVID-19 pulmonary renal syndrome Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/48678c84a2d849a985e269bf33ad8ca3
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spelling	oai:doaj.org-article:48678c84a2d849a985e269bf33ad8ca32021-11-11T07:21:02ZCase Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination2296-858X10.3389/fmed.2021.765447https://doaj.org/article/48678c84a2d849a985e269bf33ad8ca32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.765447/fullhttps://doaj.org/toc/2296-858XThe rare and severe adverse effects associated with coronavirus disease of 2019 (COVID-19) vaccination have been under-appreciated, resulting in many instances of inappropriate management. We describe the case of an elderly woman who developed anti-neutrophil cytoplasmic antibody-associated vasculitis with pulmonary renal syndrome approximately 3 weeks after the first dose of COVID-19 mRNA vaccination (Moderna). Her nasopharyngeal polymerase chain reaction test for the COVID-19 RNA virus was negative. Gross hematuria, heavy proteinuria, acute renal failure (serum creatinine up to 6.5 mg/dL), and hemoptysis coupled with a marked increase in serum anti-myeloperoxidase-O antibody were observed. Renal biopsy showed severe vasculitis with pauci-immune crescent glomerulonephritis. The pulmonary hemorrhage was resolved and renal function improved following combined plasma exchange and the administration of systemic steroids and anti-CD20 therapy. The early examination of urinalysis and renal function may be crucial for identifying glomerulonephritis and acute renal failure in susceptible patients after COVID-19 vaccination.Chien-Chou ChenChien-Chou ChenHsin-Yang ChenChun-Chi LuShih-Hua LinFrontiers Media S.A.articleanti-neutrophil cytoplasmic antibody (ANCA)vasculitisvaccinationCOVID-19pulmonary renal syndromeMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-neutrophil cytoplasmic antibody (ANCA) vasculitis vaccination COVID-19 pulmonary renal syndrome Medicine (General) R5-920
spellingShingle	anti-neutrophil cytoplasmic antibody (ANCA) vasculitis vaccination COVID-19 pulmonary renal syndrome Medicine (General) R5-920 Chien-Chou Chen Chien-Chou Chen Hsin-Yang Chen Chun-Chi Lu Shih-Hua Lin Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination
description	The rare and severe adverse effects associated with coronavirus disease of 2019 (COVID-19) vaccination have been under-appreciated, resulting in many instances of inappropriate management. We describe the case of an elderly woman who developed anti-neutrophil cytoplasmic antibody-associated vasculitis with pulmonary renal syndrome approximately 3 weeks after the first dose of COVID-19 mRNA vaccination (Moderna). Her nasopharyngeal polymerase chain reaction test for the COVID-19 RNA virus was negative. Gross hematuria, heavy proteinuria, acute renal failure (serum creatinine up to 6.5 mg/dL), and hemoptysis coupled with a marked increase in serum anti-myeloperoxidase-O antibody were observed. Renal biopsy showed severe vasculitis with pauci-immune crescent glomerulonephritis. The pulmonary hemorrhage was resolved and renal function improved following combined plasma exchange and the administration of systemic steroids and anti-CD20 therapy. The early examination of urinalysis and renal function may be crucial for identifying glomerulonephritis and acute renal failure in susceptible patients after COVID-19 vaccination.
format	article
author	Chien-Chou Chen Chien-Chou Chen Hsin-Yang Chen Chun-Chi Lu Shih-Hua Lin
author_facet	Chien-Chou Chen Chien-Chou Chen Hsin-Yang Chen Chun-Chi Lu Shih-Hua Lin
author_sort	Chien-Chou Chen
title	Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination
title_short	Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination
title_full	Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination
title_fullStr	Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination
title_full_unstemmed	Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination
title_sort	case report: anti-neutrophil cytoplasmic antibody-associated vasculitis with acute renal failure and pulmonary hemorrhage may occur after covid-19 vaccination
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/48678c84a2d849a985e269bf33ad8ca3
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Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination

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