FSC231 alleviates paclitaxel‐induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK‐3β and ERK1/2

Abstract Background FSC231, a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of protein kinase Cα interacting protein 1 (PICK1), has analgesic effects, but the mechanism remains unclear. Methods The expression level of PICK1 in dorsal root ganglion (DRG) of rats was changed by vector plasmid, and the effect...

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Autores principales: Xi Zhang, Jiagao Wang, Ran Ran, Yuchuan Peng, Yun Xiao
Formato: article
Lenguaje:EN
Publicado: Wiley 2021
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Acceso en línea:https://doaj.org/article/4868e715503d4de28112596ba3d4548e
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