Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection

Abstract HIV/SIV infections lead to massive loss of mucosal CD4 + T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of one of the most understudied mucosal environments,...

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Autores principales:	Rhianna Jones, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, Daniel R. Ram, Cordelia Manickam, Valerie Varner, Nichole R. Klatt, R. Keith Reeves
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/48692deb9b0a4041ad526778e7eb2847
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spelling	oai:doaj.org-article:48692deb9b0a4041ad526778e7eb28472021-12-02T16:08:08ZProbiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection10.1038/s41598-021-93918-x2045-2322https://doaj.org/article/48692deb9b0a4041ad526778e7eb28472021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93918-xhttps://doaj.org/toc/2045-2322Abstract HIV/SIV infections lead to massive loss of mucosal CD4 + T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of one of the most understudied mucosal environments, the oral cavity, during HIV-induced immunosuppression results in significant microbial and neoplastic co-morbidities and contributes to and predicts distal disease complications. In this study we evaluated the effects of oral probiotic supplementation (PBX), which can stimulate and augment inflammatory or anti-inflammatory pathways, on early SIV infection of rhesus macaques. Our study revealed that similar to the GI mucosae, oral CD4 + T cells were rapidly depleted, and as one of the first comprehensive analyses of the oral microflora in SIV infection, we also observed significant modulation among two genera, Porphyromonas and Actinobacillus, early after infection. Interestingly, although PBX therapy did not substantially protect against oral dysbiosis or ameliorate cell loss, it did somewhat dampen inflammation and T cell activation. Collectively, these data provide one of the most comprehensive evaluations of SIV-induced changes in oral microbiome and CD4 + T cell populations, and also suggest that oral PBX may have some anti-inflammatory properties in lentivirus infections.Rhianna JonesKyle KrollCourtney BroedlowLuca SchifanellaScott SmithBrady HueberSpandan V. ShahDaniel R. RamCordelia ManickamValerie VarnerNichole R. KlattR. Keith ReevesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rhianna Jones Kyle Kroll Courtney Broedlow Luca Schifanella Scott Smith Brady Hueber Spandan V. Shah Daniel R. Ram Cordelia Manickam Valerie Varner Nichole R. Klatt R. Keith Reeves Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection
description	Abstract HIV/SIV infections lead to massive loss of mucosal CD4 + T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of one of the most understudied mucosal environments, the oral cavity, during HIV-induced immunosuppression results in significant microbial and neoplastic co-morbidities and contributes to and predicts distal disease complications. In this study we evaluated the effects of oral probiotic supplementation (PBX), which can stimulate and augment inflammatory or anti-inflammatory pathways, on early SIV infection of rhesus macaques. Our study revealed that similar to the GI mucosae, oral CD4 + T cells were rapidly depleted, and as one of the first comprehensive analyses of the oral microflora in SIV infection, we also observed significant modulation among two genera, Porphyromonas and Actinobacillus, early after infection. Interestingly, although PBX therapy did not substantially protect against oral dysbiosis or ameliorate cell loss, it did somewhat dampen inflammation and T cell activation. Collectively, these data provide one of the most comprehensive evaluations of SIV-induced changes in oral microbiome and CD4 + T cell populations, and also suggest that oral PBX may have some anti-inflammatory properties in lentivirus infections.
format	article
author	Rhianna Jones Kyle Kroll Courtney Broedlow Luca Schifanella Scott Smith Brady Hueber Spandan V. Shah Daniel R. Ram Cordelia Manickam Valerie Varner Nichole R. Klatt R. Keith Reeves
author_facet	Rhianna Jones Kyle Kroll Courtney Broedlow Luca Schifanella Scott Smith Brady Hueber Spandan V. Shah Daniel R. Ram Cordelia Manickam Valerie Varner Nichole R. Klatt R. Keith Reeves
author_sort	Rhianna Jones
title	Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection
title_short	Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection
title_full	Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection
title_fullStr	Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection
title_full_unstemmed	Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection
title_sort	probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during siv infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/48692deb9b0a4041ad526778e7eb2847
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Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection

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