VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

Autophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has an important role in lipid metabolism in the liver....

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Autores principales:	Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/48717331846c4d5699d2e8a3c33c5192
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spelling	oai:doaj.org-article:48717331846c4d5699d2e8a3c33c51922021-12-02T13:34:55ZVPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism10.1038/s41467-021-21715-12041-1723https://doaj.org/article/48717331846c4d5699d2e8a3c33c51922021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21715-1https://doaj.org/toc/2041-1723Autophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has an important role in lipid metabolism in the liver.Yu-Hsuan ChenTzu-Yu HuangYu-Tung LinShu-Yu LinWen-Hsin LiHsiang-Jung HsiaoRuei-Liang YanHong-Wen TangZhao-Qing ShenGuang-Chao ChenKuen-Phon WuTing-Fen TsaiRuey-Hwa ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Hsuan Chen Tzu-Yu Huang Yu-Tung Lin Shu-Yu Lin Wen-Hsin Li Hsiang-Jung Hsiao Ruei-Liang Yan Hong-Wen Tang Zhao-Qing Shen Guang-Chao Chen Kuen-Phon Wu Ting-Fen Tsai Ruey-Hwa Chen VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
description	Autophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has an important role in lipid metabolism in the liver.
format	article
author	Yu-Hsuan Chen Tzu-Yu Huang Yu-Tung Lin Shu-Yu Lin Wen-Hsin Li Hsiang-Jung Hsiao Ruei-Liang Yan Hong-Wen Tang Zhao-Qing Shen Guang-Chao Chen Kuen-Phon Wu Ting-Fen Tsai Ruey-Hwa Chen
author_facet	Yu-Hsuan Chen Tzu-Yu Huang Yu-Tung Lin Shu-Yu Lin Wen-Hsin Li Hsiang-Jung Hsiao Ruei-Liang Yan Hong-Wen Tang Zhao-Qing Shen Guang-Chao Chen Kuen-Phon Wu Ting-Fen Tsai Ruey-Hwa Chen
author_sort	Yu-Hsuan Chen
title	VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
title_short	VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
title_full	VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
title_fullStr	VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
title_full_unstemmed	VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
title_sort	vps34 k29/k48 branched ubiquitination governed by ube3c and trabid regulates autophagy, proteostasis and liver metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/48717331846c4d5699d2e8a3c33c5192
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VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

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