Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis
Introduction: Vaccination seems to be a good solution for preventing and controlling coronavirus disease (COVID-19) pandemic, but still there are some challenges in COVID-19 vaccination. Investigating new therapeutic options for COVID-19 is necessary. The current study aimed to evaluate the safety a...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:487689ee5b9141b5ab71bf17817729152021-12-01T12:25:38ZStem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis2296-858X10.3389/fmed.2021.737590https://doaj.org/article/487689ee5b9141b5ab71bf17817729152021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.737590/fullhttps://doaj.org/toc/2296-858XIntroduction: Vaccination seems to be a good solution for preventing and controlling coronavirus disease (COVID-19) pandemic, but still there are some challenges in COVID-19 vaccination. Investigating new therapeutic options for COVID-19 is necessary. The current study aimed to evaluate the safety and efficacy of stem cells in treating patients with COVID-19.Methods: We reviewed the relevant scientific literature published up to April 1, 2021. The pooled risk ratio (RR) with 95% CI was assessed using a fixed or random-effect model. We considered P < 0.05 as statistically significant for publication bias. Data were analyzed by Comprehensive Meta-Analysis software, Version 2.0 (Biostat, Englewood, NJ).Results: After reviewing 1,262 records, we identified 10 studies that met the inclusion criteria. The analysis showed that stem cell therapy could significantly reduce the mortality rate (RR 0.471, 95% CI: 0.270–0.821) and morbidity (RR 0.788, 95% CI: 0.626–0.992) in patients with COVID-19; compared with the control group.Conclusions: The present study suggests that stem cell therapy has a remarkable effect on reducing mortality and morbidity of patients with COVID-19. Further large-scale studies are needed to approve these results. Defining a protocol for stem cell therapy in patients with COVID-19 can lead to achieving the best clinical outcomes.Erfan ArabpourSina KhoshdelNegin TabatabaieAli AkhgarzadMoein ZangiabadianMohammad Javad NasiriFrontiers Media S.A.articlestem cellmesenchymal stem cellcell therapyCOVID-19SARS-CoV-22019 novel coronavirusMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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DOAJ |
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EN |
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stem cell mesenchymal stem cell cell therapy COVID-19 SARS-CoV-2 2019 novel coronavirus Medicine (General) R5-920 |
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stem cell mesenchymal stem cell cell therapy COVID-19 SARS-CoV-2 2019 novel coronavirus Medicine (General) R5-920 Erfan Arabpour Sina Khoshdel Negin Tabatabaie Ali Akhgarzad Moein Zangiabadian Mohammad Javad Nasiri Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis |
| description |
Introduction: Vaccination seems to be a good solution for preventing and controlling coronavirus disease (COVID-19) pandemic, but still there are some challenges in COVID-19 vaccination. Investigating new therapeutic options for COVID-19 is necessary. The current study aimed to evaluate the safety and efficacy of stem cells in treating patients with COVID-19.Methods: We reviewed the relevant scientific literature published up to April 1, 2021. The pooled risk ratio (RR) with 95% CI was assessed using a fixed or random-effect model. We considered P < 0.05 as statistically significant for publication bias. Data were analyzed by Comprehensive Meta-Analysis software, Version 2.0 (Biostat, Englewood, NJ).Results: After reviewing 1,262 records, we identified 10 studies that met the inclusion criteria. The analysis showed that stem cell therapy could significantly reduce the mortality rate (RR 0.471, 95% CI: 0.270–0.821) and morbidity (RR 0.788, 95% CI: 0.626–0.992) in patients with COVID-19; compared with the control group.Conclusions: The present study suggests that stem cell therapy has a remarkable effect on reducing mortality and morbidity of patients with COVID-19. Further large-scale studies are needed to approve these results. Defining a protocol for stem cell therapy in patients with COVID-19 can lead to achieving the best clinical outcomes. |
| format |
article |
| author |
Erfan Arabpour Sina Khoshdel Negin Tabatabaie Ali Akhgarzad Moein Zangiabadian Mohammad Javad Nasiri |
| author_facet |
Erfan Arabpour Sina Khoshdel Negin Tabatabaie Ali Akhgarzad Moein Zangiabadian Mohammad Javad Nasiri |
| author_sort |
Erfan Arabpour |
| title |
Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis |
| title_short |
Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis |
| title_full |
Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis |
| title_fullStr |
Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis |
| title_full_unstemmed |
Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis |
| title_sort |
stem cells therapy for covid-19: a systematic review and meta-analysis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/487689ee5b9141b5ab71bf1781772915 |
| work_keys_str_mv |
AT erfanarabpour stemcellstherapyforcovid19asystematicreviewandmetaanalysis AT sinakhoshdel stemcellstherapyforcovid19asystematicreviewandmetaanalysis AT negintabatabaie stemcellstherapyforcovid19asystematicreviewandmetaanalysis AT aliakhgarzad stemcellstherapyforcovid19asystematicreviewandmetaanalysis AT moeinzangiabadian stemcellstherapyforcovid19asystematicreviewandmetaanalysis AT mohammadjavadnasiri stemcellstherapyforcovid19asystematicreviewandmetaanalysis |
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1718405170524585984 |