The Role of Apelin in the Functioning of the Reproductive System

Adipokine apelin through the apelin receptors activates a wide range of signaling cascades in the target cells and controls their growth, differentiation, apoptosis, and energy metabolism. In the recent years, the evidence has been obtained that all components of the hypothalamic-pituitary-gonad axi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. O. Shpakov, K. V. Derkach
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	apelin apelin receptor steroidogenesis ovaries endometriosis Science Q
Acceso en línea:	https://doaj.org/article/48782c95e3414e73a084c243b8332b67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:48782c95e3414e73a084c243b8332b67
record_format	dspace
spelling	oai:doaj.org-article:48782c95e3414e73a084c243b8332b672021-11-23T06:14:42ZThe Role of Apelin in the Functioning of the Reproductive System2541-94202587-959610.29413/ABS.2019-4.3.1https://doaj.org/article/48782c95e3414e73a084c243b8332b672019-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2079https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Adipokine apelin through the apelin receptors activates a wide range of signaling cascades in the target cells and controls their growth, differentiation, apoptosis, and energy metabolism. In the recent years, the evidence has been obtained that all components of the hypothalamic-pituitary-gonad axis, in which apelin and its receptor are expressed, are targets of apelin. In the hypothalamus, apelin modulates the activity of the melanocortin and ghrelin systems and indirectly affects the production of gonadoliberin. In the ovaries, it controls the growth and maturation of the follicles, stimulates the angiogenesis, and affects the basal and stimulated by the other factors steroidogenic activity in follicular cells. The changes in the apelin signaling system are closely associated with dysfunctions of the female reproductive system, such as polycystic ovary syndrome, endometriosis, and cancer. Information on the regulation of the male reproductive system by apelin is limited to animal studies showing the effect of apelin on the hypothalamic components of the gonad axis. The participation of apelin in the regulation of the reproductive system opens up the broad opportunities for the development of new approaches for the correction of abnormalities in this system and for the treatment of infertility.A. O. ShpakovK. V. DerkachScientific Сentre for Family Health and Human Reproduction Problemsarticleapelinapelin receptorsteroidogenesisovariesendometriosisScienceQRUActa Biomedica Scientifica, Vol 4, Iss 3, Pp 7-17 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	apelin apelin receptor steroidogenesis ovaries endometriosis Science Q
spellingShingle	apelin apelin receptor steroidogenesis ovaries endometriosis Science Q A. O. Shpakov K. V. Derkach The Role of Apelin in the Functioning of the Reproductive System
description	Adipokine apelin through the apelin receptors activates a wide range of signaling cascades in the target cells and controls their growth, differentiation, apoptosis, and energy metabolism. In the recent years, the evidence has been obtained that all components of the hypothalamic-pituitary-gonad axis, in which apelin and its receptor are expressed, are targets of apelin. In the hypothalamus, apelin modulates the activity of the melanocortin and ghrelin systems and indirectly affects the production of gonadoliberin. In the ovaries, it controls the growth and maturation of the follicles, stimulates the angiogenesis, and affects the basal and stimulated by the other factors steroidogenic activity in follicular cells. The changes in the apelin signaling system are closely associated with dysfunctions of the female reproductive system, such as polycystic ovary syndrome, endometriosis, and cancer. Information on the regulation of the male reproductive system by apelin is limited to animal studies showing the effect of apelin on the hypothalamic components of the gonad axis. The participation of apelin in the regulation of the reproductive system opens up the broad opportunities for the development of new approaches for the correction of abnormalities in this system and for the treatment of infertility.
format	article
author	A. O. Shpakov K. V. Derkach
author_facet	A. O. Shpakov K. V. Derkach
author_sort	A. O. Shpakov
title	The Role of Apelin in the Functioning of the Reproductive System
title_short	The Role of Apelin in the Functioning of the Reproductive System
title_full	The Role of Apelin in the Functioning of the Reproductive System
title_fullStr	The Role of Apelin in the Functioning of the Reproductive System
title_full_unstemmed	The Role of Apelin in the Functioning of the Reproductive System
title_sort	role of apelin in the functioning of the reproductive system
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/48782c95e3414e73a084c243b8332b67
work_keys_str_mv	AT aoshpakov theroleofapelininthefunctioningofthereproductivesystem AT kvderkach theroleofapelininthefunctioningofthereproductivesystem AT aoshpakov roleofapelininthefunctioningofthereproductivesystem AT kvderkach roleofapelininthefunctioningofthereproductivesystem
_version_	1718416940327763968

The Role of Apelin in the Functioning of the Reproductive System

Ejemplares similares