Long-term glycemic control and factors, associated with response to pump insulin therapy in children

Background: In recent years, pump-based insulin therapy, also known as continuous subcutaneous insulin infusion (CSII), has become a common treatment for children with type 1 diabetes mellitus (T1DM). Despite the fact that, in general, children with type 1 diabetes achieve the best glycemic control...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	D. N. Laptev, A. O. Emelyanov, E D Medvedeva, S. V. Pereverzeva, V. A. Peterkova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	type 1 diabetes mellitus diabetes mellitus in children and adolescents insulin pump therapy csii cgm Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/48784d4c5f59436e8c4474306ff2050c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:48784d4c5f59436e8c4474306ff2050c
record_format	dspace
spelling	oai:doaj.org-article:48784d4c5f59436e8c4474306ff2050c2021-11-14T09:00:23ZLong-term glycemic control and factors, associated with response to pump insulin therapy in children2072-03512072-037810.14341/DM12530https://doaj.org/article/48784d4c5f59436e8c4474306ff2050c2021-07-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12530https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background: In recent years, pump-based insulin therapy, also known as continuous subcutaneous insulin infusion (CSII), has become a common treatment for children with type 1 diabetes mellitus (T1DM). Despite the fact that, in general, children with type 1 diabetes achieve the best glycemic control indices during pump therapy, while there is a significant heterogeneity of metabolic outcomes among individual patients, many children with CSII do not reach the target level of HbA1c.Objective: To assess the level of glycemic control and factors associated by withdrawal of use, the response to treatment with prolonged use of CSII in children with type 1 diabetes.Materials and methods: The study included 458 children aged 1 to 18 years, treated to pump therapy at least 3 years before the study, the presence of the analyzed data in the register.Results: The level of HbA1c decreased by -0.7% compared with the primary endpoint, which was accompanied by an increase in the number of patients who reached the target level of HbA1c (<7.5%) from 17% to 36%. The best response was observed for patients under 6 years of age with HbA1c over 9% for pump insulin therapy, as well as in patients who regularly use additional bolus and basal functions and CGM. The main reason for stopping the use of the insulin pump is the inconvenience of using and wearing — 47.7%. Risk factors for pump abandonment: later age of start treatment on CSII and frequent episodes of severe hypoglycemia.Conclusion: According to the results of the study, it was shown that pump therapy is an effective method of insulin therapy, which allows to achieve a lower level of HbA1c compared to the initial values.D. N. LaptevA. O. EmelyanovE D MedvedevaS. V. PereverzevaV. A. PeterkovaEndocrinology Research Centrearticletype 1 diabetes mellitusdiabetes mellitus in children and adolescentsinsulin pump therapycsiicgmNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 24, Iss 2, Pp 122-132 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus diabetes mellitus in children and adolescents insulin pump therapy csii cgm Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus diabetes mellitus in children and adolescents insulin pump therapy csii cgm Nutritional diseases. Deficiency diseases RC620-627 D. N. Laptev A. O. Emelyanov E D Medvedeva S. V. Pereverzeva V. A. Peterkova Long-term glycemic control and factors, associated with response to pump insulin therapy in children
description	Background: In recent years, pump-based insulin therapy, also known as continuous subcutaneous insulin infusion (CSII), has become a common treatment for children with type 1 diabetes mellitus (T1DM). Despite the fact that, in general, children with type 1 diabetes achieve the best glycemic control indices during pump therapy, while there is a significant heterogeneity of metabolic outcomes among individual patients, many children with CSII do not reach the target level of HbA1c.Objective: To assess the level of glycemic control and factors associated by withdrawal of use, the response to treatment with prolonged use of CSII in children with type 1 diabetes.Materials and methods: The study included 458 children aged 1 to 18 years, treated to pump therapy at least 3 years before the study, the presence of the analyzed data in the register.Results: The level of HbA1c decreased by -0.7% compared with the primary endpoint, which was accompanied by an increase in the number of patients who reached the target level of HbA1c (<7.5%) from 17% to 36%. The best response was observed for patients under 6 years of age with HbA1c over 9% for pump insulin therapy, as well as in patients who regularly use additional bolus and basal functions and CGM. The main reason for stopping the use of the insulin pump is the inconvenience of using and wearing — 47.7%. Risk factors for pump abandonment: later age of start treatment on CSII and frequent episodes of severe hypoglycemia.Conclusion: According to the results of the study, it was shown that pump therapy is an effective method of insulin therapy, which allows to achieve a lower level of HbA1c compared to the initial values.
format	article
author	D. N. Laptev A. O. Emelyanov E D Medvedeva S. V. Pereverzeva V. A. Peterkova
author_facet	D. N. Laptev A. O. Emelyanov E D Medvedeva S. V. Pereverzeva V. A. Peterkova
author_sort	D. N. Laptev
title	Long-term glycemic control and factors, associated with response to pump insulin therapy in children
title_short	Long-term glycemic control and factors, associated with response to pump insulin therapy in children
title_full	Long-term glycemic control and factors, associated with response to pump insulin therapy in children
title_fullStr	Long-term glycemic control and factors, associated with response to pump insulin therapy in children
title_full_unstemmed	Long-term glycemic control and factors, associated with response to pump insulin therapy in children
title_sort	long-term glycemic control and factors, associated with response to pump insulin therapy in children
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/48784d4c5f59436e8c4474306ff2050c
work_keys_str_mv	AT dnlaptev longtermglycemiccontrolandfactorsassociatedwithresponsetopumpinsulintherapyinchildren AT aoemelyanov longtermglycemiccontrolandfactorsassociatedwithresponsetopumpinsulintherapyinchildren AT edmedvedeva longtermglycemiccontrolandfactorsassociatedwithresponsetopumpinsulintherapyinchildren AT svpereverzeva longtermglycemiccontrolandfactorsassociatedwithresponsetopumpinsulintherapyinchildren AT vapeterkova longtermglycemiccontrolandfactorsassociatedwithresponsetopumpinsulintherapyinchildren
_version_	1718429461499609088

Long-term glycemic control and factors, associated with response to pump insulin therapy in children

Ejemplares similares