Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer

Background and purpose: Radiation damage to neural and vascular tissue, such as the neurovascular bundles (NVBs) and internal pudendal arteries (IPAs), during radiotherapy for prostate cancer (PCa) may cause erectile dysfunction. Neurovascular-sparing magnetic resonance-guided adaptive radiotherapy...

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Autores principales:	F.R. Teunissen, R.C. Wortel, F.J. Wessels, A. Claes, S.M.G. van de Pol, M.J.A. Rasing, R.P. Meijer, H.H.E. van Melick, J.C.J. de Boer, H.M. Verkooijen, J.R.N. van der Voort van Zyp
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Localized prostate cancer (PCa) Magnetic resonance-guided radiotherapy (MRgRT) Interrater agreement Neurovascular bundle (NVB) Internal pudendal artery (IPA) Neurovascular-sparing Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4879a12caf764a1488638937ac6c7b1f
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spelling	oai:doaj.org-article:4879a12caf764a1488638937ac6c7b1f2021-11-18T04:50:33ZInterrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer2405-630810.1016/j.ctro.2021.11.005https://doaj.org/article/4879a12caf764a1488638937ac6c7b1f2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405630821000963https://doaj.org/toc/2405-6308Background and purpose: Radiation damage to neural and vascular tissue, such as the neurovascular bundles (NVBs) and internal pudendal arteries (IPAs), during radiotherapy for prostate cancer (PCa) may cause erectile dysfunction. Neurovascular-sparing magnetic resonance-guided adaptive radiotherapy (MRgRT) aims to preserve erectile function after treatment. However, the NVBs and IPAs are not routinely contoured in current radiotherapy practice. Before neurovascular-sparing MRgRT for PCa can be implemented, the interrater agreement of the contouring of the NVBs and IPAs on pre-treatment MRI needs to be assessed. Materials and methods: Four radiation oncologists independently contoured the prostate, NVB, and IPA in an unselected consecutive series of 15 PCa patients, on pre-treatment MRI. Dice similarity coefficients (DSCs) for pairwise interrater agreement of contours were calculated. Additionally, the DCS of a subset of the inferior half of the NVB contours (i.e. approximately prostate midgland to apex level) was calculated. Results: Median overall interrater DSC for the left and right NVB was 0.60 (IQR: 0.54 – 0.68) and 0.61 (IQR: 0.53 – 0.69) respectively and for the left and right IPA 0.59 (IQR: 0.53 – 0.64) and 0.59 (IQR: 0.52 – 0.64) respectively. Median overall interrater DSC for the inferior half of the left NVB was 0.67 (IQR: 0.58 – 0.74) and 0.67 (IQR: 0.61 – 0.71) for the right NVB. Conclusion: We found that the interrater agreement for the contouring of the NVB and IPA improved with enhancement of the MRI sequence as well as further training of the raters. The agreement was best in the subset of the inferior half of the NVB, where a good agreement is clinically most relevant for neurovascular-sparing MRgRT for PCa.F.R. TeunissenR.C. WortelF.J. WesselsA. ClaesS.M.G. van de PolM.J.A. RasingR.P. MeijerH.H.E. van MelickJ.C.J. de BoerH.M. VerkooijenJ.R.N. van der Voort van ZypElsevierarticleLocalized prostate cancer (PCa)Magnetic resonance-guided radiotherapy (MRgRT)Interrater agreementNeurovascular bundle (NVB)Internal pudendal artery (IPA)Neurovascular-sparingMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENClinical and Translational Radiation Oncology, Vol 32, Iss , Pp 29-34 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Localized prostate cancer (PCa) Magnetic resonance-guided radiotherapy (MRgRT) Interrater agreement Neurovascular bundle (NVB) Internal pudendal artery (IPA) Neurovascular-sparing Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Localized prostate cancer (PCa) Magnetic resonance-guided radiotherapy (MRgRT) Interrater agreement Neurovascular bundle (NVB) Internal pudendal artery (IPA) Neurovascular-sparing Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 F.R. Teunissen R.C. Wortel F.J. Wessels A. Claes S.M.G. van de Pol M.J.A. Rasing R.P. Meijer H.H.E. van Melick J.C.J. de Boer H.M. Verkooijen J.R.N. van der Voort van Zyp Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer
description	Background and purpose: Radiation damage to neural and vascular tissue, such as the neurovascular bundles (NVBs) and internal pudendal arteries (IPAs), during radiotherapy for prostate cancer (PCa) may cause erectile dysfunction. Neurovascular-sparing magnetic resonance-guided adaptive radiotherapy (MRgRT) aims to preserve erectile function after treatment. However, the NVBs and IPAs are not routinely contoured in current radiotherapy practice. Before neurovascular-sparing MRgRT for PCa can be implemented, the interrater agreement of the contouring of the NVBs and IPAs on pre-treatment MRI needs to be assessed. Materials and methods: Four radiation oncologists independently contoured the prostate, NVB, and IPA in an unselected consecutive series of 15 PCa patients, on pre-treatment MRI. Dice similarity coefficients (DSCs) for pairwise interrater agreement of contours were calculated. Additionally, the DCS of a subset of the inferior half of the NVB contours (i.e. approximately prostate midgland to apex level) was calculated. Results: Median overall interrater DSC for the left and right NVB was 0.60 (IQR: 0.54 – 0.68) and 0.61 (IQR: 0.53 – 0.69) respectively and for the left and right IPA 0.59 (IQR: 0.53 – 0.64) and 0.59 (IQR: 0.52 – 0.64) respectively. Median overall interrater DSC for the inferior half of the left NVB was 0.67 (IQR: 0.58 – 0.74) and 0.67 (IQR: 0.61 – 0.71) for the right NVB. Conclusion: We found that the interrater agreement for the contouring of the NVB and IPA improved with enhancement of the MRI sequence as well as further training of the raters. The agreement was best in the subset of the inferior half of the NVB, where a good agreement is clinically most relevant for neurovascular-sparing MRgRT for PCa.
format	article
author	F.R. Teunissen R.C. Wortel F.J. Wessels A. Claes S.M.G. van de Pol M.J.A. Rasing R.P. Meijer H.H.E. van Melick J.C.J. de Boer H.M. Verkooijen J.R.N. van der Voort van Zyp
author_facet	F.R. Teunissen R.C. Wortel F.J. Wessels A. Claes S.M.G. van de Pol M.J.A. Rasing R.P. Meijer H.H.E. van Melick J.C.J. de Boer H.M. Verkooijen J.R.N. van der Voort van Zyp
author_sort	F.R. Teunissen
title	Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer
title_short	Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer
title_full	Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer
title_fullStr	Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer
title_full_unstemmed	Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer
title_sort	interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/4879a12caf764a1488638937ac6c7b1f
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Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer

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