Somatic inhibition by microscopic magnetic stimulation

Abstract Electric currents can produce quick, reversible control of neural activity. Externally applied electric currents have been used in inhibiting certain ganglion cells in clinical practices. Via electromagnetic induction, a miniature-sized magnetic coil could provide focal stimulation to the g...

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Autores principales:	Hui Ye, Lauryn Barrett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/48816cc6b448415c84fe668aeb17bf2e
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spelling	oai:doaj.org-article:48816cc6b448415c84fe668aeb17bf2e2021-12-02T14:33:57ZSomatic inhibition by microscopic magnetic stimulation10.1038/s41598-021-93114-x2045-2322https://doaj.org/article/48816cc6b448415c84fe668aeb17bf2e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93114-xhttps://doaj.org/toc/2045-2322Abstract Electric currents can produce quick, reversible control of neural activity. Externally applied electric currents have been used in inhibiting certain ganglion cells in clinical practices. Via electromagnetic induction, a miniature-sized magnetic coil could provide focal stimulation to the ganglion neurons. Here we report that high-frequency stimulation with the miniature coil could reversibly block ganglion cell activity in marine mollusk Aplysia californica, regardless the firing frequency of the neurons, or concentration of potassium ions around the ganglion neurons. Presence of the ganglion sheath has minimal impact on the inhibitory effects of the coil. The inhibitory effect was local to the soma, and was sufficient in blocking the neuron’s functional output. Biophysical modeling confirmed that the miniature coil induced a sufficient electric field in the vicinity of the targeted soma. Using a multi-compartment model of Aplysia ganglion neuron, we found that the high-frequency magnetic stimuli altered the ion channel dynamics that were essential for the sustained firing of action potentials in the soma. Results from this study produces several critical insights to further developing the miniature coil technology for neural control by targeting ganglion cells. The miniature coil provides an interesting neural modulation strategy in clinical applications and laboratory research.Hui YeLauryn BarrettNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui Ye Lauryn Barrett Somatic inhibition by microscopic magnetic stimulation
description	Abstract Electric currents can produce quick, reversible control of neural activity. Externally applied electric currents have been used in inhibiting certain ganglion cells in clinical practices. Via electromagnetic induction, a miniature-sized magnetic coil could provide focal stimulation to the ganglion neurons. Here we report that high-frequency stimulation with the miniature coil could reversibly block ganglion cell activity in marine mollusk Aplysia californica, regardless the firing frequency of the neurons, or concentration of potassium ions around the ganglion neurons. Presence of the ganglion sheath has minimal impact on the inhibitory effects of the coil. The inhibitory effect was local to the soma, and was sufficient in blocking the neuron’s functional output. Biophysical modeling confirmed that the miniature coil induced a sufficient electric field in the vicinity of the targeted soma. Using a multi-compartment model of Aplysia ganglion neuron, we found that the high-frequency magnetic stimuli altered the ion channel dynamics that were essential for the sustained firing of action potentials in the soma. Results from this study produces several critical insights to further developing the miniature coil technology for neural control by targeting ganglion cells. The miniature coil provides an interesting neural modulation strategy in clinical applications and laboratory research.
format	article
author	Hui Ye Lauryn Barrett
author_facet	Hui Ye Lauryn Barrett
author_sort	Hui Ye
title	Somatic inhibition by microscopic magnetic stimulation
title_short	Somatic inhibition by microscopic magnetic stimulation
title_full	Somatic inhibition by microscopic magnetic stimulation
title_fullStr	Somatic inhibition by microscopic magnetic stimulation
title_full_unstemmed	Somatic inhibition by microscopic magnetic stimulation
title_sort	somatic inhibition by microscopic magnetic stimulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/48816cc6b448415c84fe668aeb17bf2e
work_keys_str_mv	AT huiye somaticinhibitionbymicroscopicmagneticstimulation AT laurynbarrett somaticinhibitionbymicroscopicmagneticstimulation
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Somatic inhibition by microscopic magnetic stimulation

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