The Lung Elastin Matrix Undergoes Rapid Degradation Upon Adult Loss of Hox5 Function

Hox genes encode transcription factors that are critical for embryonic skeletal patterning and organogenesis. The Hoxa5, Hoxb5, and Hoxc5 paralogs are expressed in the lung mesenchyme and function redundantly during embryonic lung development. Conditional loss-of-function of these genes during postn...

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Autores principales: Mu-Hang Li, Leilani M. Marty-Santos, Paul R. van Ginkel, Aubrey E. McDermott, Andrew J. Rasky, Nicholas W. Lukacs, Deneen M. Wellik
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/4881e5a53fd44504b5e9e770a665a0b8
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