Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis

Background: Certain studies suggest that percutaneous absorption of topical steroids may cause suppression of hypothalamic–pituitary–adrenal axis (HPAA) in atopic dermatitis (AD) patients. This study aimed to investigate the basal serum cortisol, adrenocorticotropic hormone (ACTH), and IgE levels i...

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Autores principales:	Zohreh Tehranchinia, Hoda Rahimi, Sara Lotfi
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2017
Materias:	adrenocorticotropic hormone atopic dermatitis cortisol IgE Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/4882fd1a97f94ec59f957c4e64479b53
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spelling	oai:doaj.org-article:4882fd1a97f94ec59f957c4e64479b532021-11-17T08:30:36ZBasal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis10.5826/dpc.0704a072160-9381https://doaj.org/article/4882fd1a97f94ec59f957c4e64479b532017-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/246https://doaj.org/toc/2160-9381 Background: Certain studies suggest that percutaneous absorption of topical steroids may cause suppression of hypothalamic–pituitary–adrenal axis (HPAA) in atopic dermatitis (AD) patients. This study aimed to investigate the basal serum cortisol, adrenocorticotropic hormone (ACTH), and IgE levels in patients with AD and their correlation with the disease severity. Methods: Levels of basal serum cortisol, ACTH, and IgE were assessed by ELISA in 31 patients with AD and 31 controls. Clinical severity of AD was evaluated by the scoring of atopic dermatitis (SCORAD) index. Results: No statistical difference was observed between the two groups for basal serum cortisol and ACTH levels. The serum IgE level was significantly higher in the AD group. The SCORAD index was correlated with serum IgE level. Conclusions: Basal serum cortisol and ACTH levels are normal in AD patients. Serum IgE level is significantly higher in AD patients and is correlated with the disease severity. Zohreh TehranchiniaHoda RahimiSara LotfiMattioli1885articleadrenocorticotropic hormoneatopic dermatitiscortisolIgEDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 7, Iss 4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	adrenocorticotropic hormone atopic dermatitis cortisol IgE Dermatology RL1-803
spellingShingle	adrenocorticotropic hormone atopic dermatitis cortisol IgE Dermatology RL1-803 Zohreh Tehranchinia Hoda Rahimi Sara Lotfi Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis
description	Background: Certain studies suggest that percutaneous absorption of topical steroids may cause suppression of hypothalamic–pituitary–adrenal axis (HPAA) in atopic dermatitis (AD) patients. This study aimed to investigate the basal serum cortisol, adrenocorticotropic hormone (ACTH), and IgE levels in patients with AD and their correlation with the disease severity. Methods: Levels of basal serum cortisol, ACTH, and IgE were assessed by ELISA in 31 patients with AD and 31 controls. Clinical severity of AD was evaluated by the scoring of atopic dermatitis (SCORAD) index. Results: No statistical difference was observed between the two groups for basal serum cortisol and ACTH levels. The serum IgE level was significantly higher in the AD group. The SCORAD index was correlated with serum IgE level. Conclusions: Basal serum cortisol and ACTH levels are normal in AD patients. Serum IgE level is significantly higher in AD patients and is correlated with the disease severity.
format	article
author	Zohreh Tehranchinia Hoda Rahimi Sara Lotfi
author_facet	Zohreh Tehranchinia Hoda Rahimi Sara Lotfi
author_sort	Zohreh Tehranchinia
title	Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis
title_short	Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis
title_full	Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis
title_fullStr	Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis
title_full_unstemmed	Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis
title_sort	basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis
publisher	Mattioli1885
publishDate	2017
url	https://doaj.org/article/4882fd1a97f94ec59f957c4e64479b53
work_keys_str_mv	AT zohrehtehranchinia basalserumcortisolandadrenocorticotropichormonelevelsinpatientswithatopicdermatitis AT hodarahimi basalserumcortisolandadrenocorticotropichormonelevelsinpatientswithatopicdermatitis AT saralotfi basalserumcortisolandadrenocorticotropichormonelevelsinpatientswithatopicdermatitis
_version_	1718425731608870912

Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis

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