Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase

Pajed et al. investigate the role of adipocyte hormone-sensitive lipase (HSL) in whole body energy homeostasis. They show that adipocyte-specific HSL Knockout (AHKO) mice fed high fat diet develop fatty liver. Interestingly, this phenotype reverses in aged AHKO mice, possibly due to blunted lipolyti...

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Autores principales:	Laura Pajed, Ulrike Taschler, Anna Tilp, Peter Hofer, Petra Kotzbeck, Stephanie Kolleritsch, Franz P. W. Radner, Isabella Pototschnig, Carina Wagner, Margarita Schratter, Sandra Eder, Sabrina Huetter, Renate Schreiber, Guenter Haemmerle, Thomas O. Eichmann, Martina Schweiger, Gerald Hoefler, Erin E. Kershaw, Achim Lass, Gabriele Schoiswohl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/489219dde80844a090448c922d5f0fbd
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spelling	oai:doaj.org-article:489219dde80844a090448c922d5f0fbd2021-12-02T15:52:58ZAdvanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase10.1038/s42003-021-01858-z2399-3642https://doaj.org/article/489219dde80844a090448c922d5f0fbd2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01858-zhttps://doaj.org/toc/2399-3642Pajed et al. investigate the role of adipocyte hormone-sensitive lipase (HSL) in whole body energy homeostasis. They show that adipocyte-specific HSL Knockout (AHKO) mice fed high fat diet develop fatty liver. Interestingly, this phenotype reverses in aged AHKO mice, possibly due to blunted lipolytic activity in adipose tissue with pronounced lipodystrophy.Laura PajedUlrike TaschlerAnna TilpPeter HoferPetra KotzbeckStephanie KolleritschFranz P. W. RadnerIsabella PototschnigCarina WagnerMargarita SchratterSandra EderSabrina HuetterRenate SchreiberGuenter HaemmerleThomas O. EichmannMartina SchweigerGerald HoeflerErin E. KershawAchim LassGabriele SchoiswohlNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Laura Pajed Ulrike Taschler Anna Tilp Peter Hofer Petra Kotzbeck Stephanie Kolleritsch Franz P. W. Radner Isabella Pototschnig Carina Wagner Margarita Schratter Sandra Eder Sabrina Huetter Renate Schreiber Guenter Haemmerle Thomas O. Eichmann Martina Schweiger Gerald Hoefler Erin E. Kershaw Achim Lass Gabriele Schoiswohl Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase
description	Pajed et al. investigate the role of adipocyte hormone-sensitive lipase (HSL) in whole body energy homeostasis. They show that adipocyte-specific HSL Knockout (AHKO) mice fed high fat diet develop fatty liver. Interestingly, this phenotype reverses in aged AHKO mice, possibly due to blunted lipolytic activity in adipose tissue with pronounced lipodystrophy.
format	article
author	Laura Pajed Ulrike Taschler Anna Tilp Peter Hofer Petra Kotzbeck Stephanie Kolleritsch Franz P. W. Radner Isabella Pototschnig Carina Wagner Margarita Schratter Sandra Eder Sabrina Huetter Renate Schreiber Guenter Haemmerle Thomas O. Eichmann Martina Schweiger Gerald Hoefler Erin E. Kershaw Achim Lass Gabriele Schoiswohl
author_facet	Laura Pajed Ulrike Taschler Anna Tilp Peter Hofer Petra Kotzbeck Stephanie Kolleritsch Franz P. W. Radner Isabella Pototschnig Carina Wagner Margarita Schratter Sandra Eder Sabrina Huetter Renate Schreiber Guenter Haemmerle Thomas O. Eichmann Martina Schweiger Gerald Hoefler Erin E. Kershaw Achim Lass Gabriele Schoiswohl
author_sort	Laura Pajed
title	Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase
title_short	Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase
title_full	Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase
title_fullStr	Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase
title_full_unstemmed	Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase
title_sort	advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/489219dde80844a090448c922d5f0fbd
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Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase

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