Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that the postulated substrate specifying role of C-...

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Auteurs principaux: Mark J. Calcott, Jeremy G. Owen, David F. Ackerley
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/48924e1b8e5f493994a0d6dff8b81874
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